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It has long been recognized that solid tumors contain poorly vascularized regions characterized by severe hypoxia (oxygen deprivation), acidosis and nutrient starvation.[5] Tumor hypoxia is typically associated with poor patient prognosis. Over the past decade, work from many laboratories has indicated that hypoxic microenvironments contribute to cancer progression by activating adaptive transcriptional programs that promote cell
survival, motility and tumor angiogenesis.[6] Oxygen pulls the rug out from under cancer cells and tumors by removing the basic condition that makes them virulent.
There is no substitute for oxygen in regards to maintaining human life. If there is not an adequate amount of oxygen in a cell, then energy production is unavoidably restricted (just as any fire must have ample oxygen in
order to continue to burn). When energy production is inadequate to meet cellular needs, then many cell operations do not proceed normally, allowing cancer and other diseases to occur.
Cancer, cardiovascular disease, Parkinson's, Alzheimer's and much more are all potential results of inadequate cellular oxygenation. These diseases of inadequate oxygenation cause untold suffering and loss of life, which is avoidable when using Anti-Inflammatory Oxygen Therapy. With enough oxygen, we can regain our lives and our health.
It is common for people to have plenty of oxygen in their blood stream and yet have insufficient oxygen inside their cells because cell membranes have become resistant over time to the diffusion of oxygen into the cell interior. One of the principle reasons for this are massive magnesium deficiencies inside of the cells. A full protocol needs to be incorporated with oxygen to realize maximum results.
The National Institutes of Health is experimenting with targeted cancer drugs that repair damaged arteries. The University of Texas Arlington received $1.4 million to develop nanoparticles that promote healing in damaged endothelium, the lining of blood vessels. "Angioplasty and stenting often damage arterial walls, with a significant risk of subsequent complications, such as re-narrowing of the artery or blood clot," said Dr. Yang.
Platelets accumulate on the damaged vessel, initiating clot formation. Other cells can deposit on the damaged vessel wall, building up a blockage.[7] Oxygen is the ultimate nanoparticle in terms of medicine and health. It will do the job without collateral side effects that pharmaceuticals have because of their toxic origin.
Georgetown University and many other universities are testing a new class of cancer drugs called immune-checkpoint inhibitors. Stimulating the immune system works and there are reports of primary tumors fading and
patients becoming completely cancer free. Oncologists are calling this approach a breakthrough but even the most enthusiastic supporters of the checkpoint inhibitors acknowledge that about half their patients have not
benefited.
These new, sophisticated forms of molecular medicine cannot outperform oxygen, which will do the same job safely and quickly.
[1] Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK.
Chen YC et al; Leuk Res.; 2007 Jun; 31(6):805-15. Epub 2006 Oct 24.
http://www.ncbi.nlm.nih.gov/pubmed/17064767
[2] .University of Colorado Denver. "Lack of oxygen in cancer cells leads to growth and metastasis." ScienceDaily; September 13, 2012
[3] Many of the cellular responses to hypoxia are mediated through changes in gene expression. The transcription factors primarily responsible for these changes are the Hypoxia Inducible Factors (HIFs), the biology of which has been reviewed elsewhere (Pouyssegur et al., 2006; Semenza, 2003). Briefly, HIFs are members of the bHLH-PAS family of proteins, and bind to canonical DNA sequences (hypoxia regulated elements, or HREs)
in the promoters or enhancers of target genes. They consist of an alpha (HIF-α) and a beta (HIF-β, or ARNT) subunit, and activate the expression of at least 150 genes encoding proteins that regulate cell metabolism, survival, motility, basement membrane integrity, angiogenesis, hematopoiesis, and other functions. Regulation of HIF activity is mediated primarily through the stability of the alpha subunit: under conditions of abundant oxygen (>8–10%), HIF-α proteins are translated but rapidly degraded. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150586/
[4] The Hypoxic Cell. A Target for Selective Cancer Therapy—Eighteenth Bruce F. Cain Memorial Award Lecture 1
J. Martin Brown2; http://cancerres.aacrjournals.org/content/59/23/5863.full
[5] Carmeliet and Jain, 2000; Pouyssegur et al., 2006
[6] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150586/
[7] Penn State Materials Research Institute. "Researcher turns sights on prostate cancer, tissue engineering, blood vessel repair." ScienceDaily. ScienceDaily, 30 January 2014.
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