Background: Diseases of the venous system are widespread disorders sometimes associated with modern civilisation and are among the major concerns of social and occupational medicine. This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class Il and dried horse chestnut seed extract (HCSE, 50 mg aescin, twice daily).
Methods: Equivalence of both therapies was examined in a novel hierarchical statistical design in 240 patients with chronic venous insufficiency. Patients were treated over a period of 12 weeks in a randomised, partially blinded, placebo-controlled, parallel study design.
Findings: Lower leg volume of the more severely affected limb decreased on average by 43.8 mL (n= 95) with HCSE and 46.7 mL (n =99) with compression therapy, while it increased by 9.8 mL with placebo (n = 46) after 12 weeks therapy for the intention-to-treat group (95% CI: HCSE:21.1-66.4; compression: 30.4-63.0; placebo: 40.0-20.4). Significant oedema reductions were achieved by HCSE (p =0.005) and compression (p =0.002) compared to placebo, and the two therapies were shown to be equivalent (p =0.001); in this design, however, compression could not be proven as standard with regard to oedema reduction in the statistical test procedure. Both HCSE and compression therapy were well tolerated and no serious treatment-related events were reported.
This seed outperforms and swelling in the leg, is Aesculus Hippocastanum. AESCULUS HIPPOCASTANUM
Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency A meta-analysis of randomized controlled trials and large observational studies
Abstract
Safe and effective oral therapies for chronic venous insufficiency (CVI) would provide an important alternative to mechanical compression treatment. Several narrative reviews and one systematic review have summarized the efficacy of horse chestnut seed extract (HCSE), but to our knowledge no systematic review has included data from both randomized controlled trials (RCTs) and large-scale observational studies regarding outcomes as well as adverse events. Using a systematic literature search, we identified 13 RCTs of CVI (1,051 patients) and 3 observational studies (10,725 patients) that met our inclusion criteria. Examined outcomes were leg volume, ankle and calf circumference, edema, pain, sensation of tension, swelling, leg fatigue/heaviness, calf cramps, and itching. Random and fixed effect models were used to pool outcomes and adverse events separately for RCTs and observational studies. Overall, the RCTs indicated that HCSE improved symptoms in patients with CVI. Compared to placebo, HCSE reduced leg volume by 46.4 ml (95% CI, 11.3-81.4 ml) and increased the likelihood of improvement in leg pain 4.1-fold (95% CI, 0.98-16.8). Similarly, improvement probabilities were increased 1.5-fold (95% CI,1.2-1.9) for edema and 1.7-fold (95% CI, 0.01-3.0) for itching. There was insufficient evidence to demonstrate HCSE's effect on leg fatigue/heaviness or calf cramps. Observational studies showed significant effectiveness regarding pain, edema, and leg fatigue/heaviness. No severe adverse events were reported, and HCSE did not significantly increase mild adverse events. Based on meta-analysis
WILEY. Online Library
BioMed Research International
Antioxidant Activity and Total Phenolic and Flavonoid Content of Various Solvent Extracts from In Vivo and In Vitro Grown Trifolium pratense L. (Red Clover)
Abstract
In the present study the extracts of in vivo and in vitro grown plants as well as callus tissue of red clover were tested for their antioxidant activities, using different extraction solvent and different antioxidant assays. The total flavonoid and phenolic contents as well as extraction yield of the extracts were also investigated to determine their correlation with the antioxidant activity of the extracts. Among all the tested extracts the highest amounts of total phenolic and total flavonoids content were found in methanol extract of in vivo grown plants. The antioxidant activity of tested samples followed the order in vivo plant extract> callus extract> in vitro extract. The highest reducing power, 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging, and chelating power were found in methanol extracts of in vivo grown red clover, while the chloroform fraction of in vivo grown plants showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, superoxide anion radical scavenging and hydrogen peroxide scavenging compared to the other tested extracts. A significant correlation was found between the antioxidant activity of extracts and their total ... ~ BioMed Research International.
Plant called Trifolium Pratense.
TRIFOLIUM PRATENSE
Centella Asiatica Extract.
CENTELLA ASIATICA
now confirm its ability to
NIH
National Library of Medicine National Center for Biotechnology Information
Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all
Abstract
In recent times, focus on plant research has increased all over the world. Centella asiatica is an important medicinal herb that is widely used in the orient and is becoming popular in the West. Triterpenoid, saponins, the primary constituents of Centella asiatica are mainly believed to be responsible for its wide therapeutic actions. Apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever;, amenorrhea, diseases of the female genitourinary tract and also for relieving anxiety and improving cognition. The present review attempts to provide comprehensive information on pharmacology, mechanisms of action, various preclinical and clinical studies, safety precautions and current research prospects of the herb. At the same time, studies to evaluate the likelihood of interactions with drugs and herbs on simultaneous use, which is imperative for optimal and safe utilization of the herb, are discussed.
Keywords: Centella asiatica, description, herb-drug interactions, pharmacology of Centella asiatica, preclinical and clinical studies, side effects, therapeutic uses
llex paraguayensis
ILEX PARAGUAYENSIS
Recent scientific research
ELSEVIER
International Immunopharmacology
Volume 36, July 2016, Pages 165-172
The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy
Ana Beatriz Gobbo Luz, Carlos Henrique Blum da Silva, Marcus Vinicius P.S. Nascimento , Bruno Matheus de Campos Facchin ,Tânia Silvia Fröde , Flávio Henrique Reginatto , Bruna Baratto , Eduardo Monguilhott Dalmarco .
Gallium Aparine
GALIUM APARINE
is now clinically proven doesn't just reduce sweIling.
Aesculus Hippocastanum
Trifolium Pratense
Centella Asiatica
llex Paraguariensis
Galium Aparine
extracts of alI five nutrients of this edema-flushing formula we added Burdock root, Purple Cone Flower,
and Olive Leaf Extract, Ginger Root 🫚 ,
RED ROOT POWDER
STILLIRIGIA EXTRACT
and Stillirigia Extract.
combined with the
Aesculus Hippocastanum
Burdock Root
Purple Coneflower
Trifolium Pratense
Ginger Root
Centella Asiatica
Olive Leaf
llex Paraguariensis
Red Root Powder
Galium Aparine
Stillingia Extract
create a powerhouse A completely natural and effective LYMPH SAVIOR
Advanced Lymphatic Health Support
60 CAPSULES
DiETDARY SUPPLEMENT
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