Abrogation of viral infection in NACs (after short-lived virus replication) is mediated by innate immunity
sIgM
ACE: Angiotensin –converting enzyme
CSEPDM: cell surface-expressed pathogen-derived motif
DC: Dendritic cell
EC: Epithelial cell
MBC: Memory B cell
NKC: Natural Killer cell
Abrogation of viral infection at an early stage of infection is the virus’ secret weapon to ensure its own perpetuation
• Short-lived Ag-specific Abs suppress binding of CoV by NABs and hence, dampen innate immunity
• Asymptomatic infection momentarily weakens innate immunity without providing protective adaptive immunity →↑ susceptibility to disease
IV: Immune escape variant
OCS: Original circulating strain
NIV: New immune escape variant
Thin arrows: Low affinity
Thick arrows: High affinity
- Univac - Strictly Confidential
– June 2016
- Author: Dr. G. Vanden Bossche; NONCONFIDENTIAL; DO COPY; DO DISTRIBUTE
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