Say Goodbye to Constipation! Feel the smooth! --- "Vascular Cleaner Series"

 Bi-liangua 双语 Shuāngyǔ

https://m.youtube.com/watch?v=4KtWBeM9e6M&pp=sAQA

( Chinese video with subtitles of the language of your choice. Select and play.)

观看此视频就像参加 20 分钟的免费健康课程。 只要坚持练习，就可以改善肠道健康。 你会感觉更轻，而且非常光滑。 你在等什么？ 让我们开始做吧。

Watching this video is like taking a 20 minutes free health course. As long as you practice, you can improve your intestinal health. You will feel lighter, and extremely smooth. What are you waiting for? Let's start to do it.

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现代人饱受排便不规律和便秘困扰。 就算每天都排便，只要经常有结块，有残疾感（多半是不洁），排便费力，甚至借助手指（外力）排便，这些 都是便秘的症状。 排泄不规律不是局部问题，但影响是全身性的。

Xiàndài rén bǎo shòu páibiàn bù guīlǜ hé biànmì kùnrǎo. Jiùsuàn měitiān dū páibiàn, zhǐyào jīngcháng yǒu jié kuài, yǒu cánjí gǎn (duōbàn shì bù jié), páibiàn fèilì, shènzhì jièzhù shǒuzhǐ (wàilì) páibiàn, zhèxiē dōu shì biànmì de zhèngzhuàng. Páixiè bù guīlǜ bùshì júbù wèntí, dàn yǐngxiǎng shì quánshēn xìng de.

Modern people are plagued by irregular bowel movements and constipation. Even if you have a bowel movement every day, as long as there is frequent clumping, a sense of disability (largely unclean), a lot of effort is required to defecate, and even the help of fingers (external force) to defecate, these are all symptoms of constipation. Irregular excretion is not a local problem, but the effect is systemic. 

排便：专家建议用水代替卫生纸清理

Páibiàn: Zhuānjiā jiànyì yòngshuǐ dàitì wèishēngzhǐ qīnglǐ

Defecation: Expert recommends use of water for cleaning your anus instead of using toilet paper to clean up. 

Comment: If you want to keep your blood vessels elasticity in optimal condition, I recommend you to eat the citrus fruits like orange, lime, lemon, grapefruit. Orange fruits have a thick, orange-colored, outside layer called the rind. The side of the rind on the inside of the fruit is white and is called the pericarp or albedo. Don't throw the white pericarp away. Eat it. For it keeps your blood vessels elasticity at its healthiest state. But many people don't know. The orange fruit has a thin, white material attached to inside of the rind or peel that also attaches to the edible fruit flesh. This material is thread-like and is referred to as the pith. The edible flesh of the orange fruit is divided evenly into pieces, called segments or carpels. 如果你想让你的血管弹性处于最佳状态，我建议你吃柑橘类水果，如橙子、酸橙、柠檬、葡萄柚。 橙色水果有一层厚厚的橙色外层，称为果皮。 果实内部的果皮一侧是白色的，称为果皮或反照率。 不要扔掉白色的果皮。 吃了它。 因为它使您的血管弹性保持在最健康的状态。 但是很多人不知道。 橙色水果有一层薄薄的白色物质，附着在外皮或果皮的内部，也附着在可食用的果肉上。 这种材料是线状的，被称为髓。 橙子果实的可食用果肉被均匀地分成小块，称为片断或心皮。Its Me , Welcome. Invite to explore and share the blogsite here with your friends, or contacts. https://theinnozablog.blogspot.com 

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

COVID-19 患者住院期间肠道微生物群的变化

Background & aims: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gastrointestinal tissues, little is known about the roles of gut commensal microbes in susceptibility to and severity of infection. We investigated changes in fecal microbiomes of patients with SARS-CoV-2 infection during hospitalization and associations with severity and fecal shedding of virus.

Methods: We performed shotgun metagenomic sequencing analyses of fecal samples from 15 patients with Coronavirus Disease 2019 (COVID-19) in Hong Kong, from February 5 through March 17, 2020. Fecal samples were collected 2 or 3 times per week from time of hospitalization until discharge; disease was categorized as mild (no radiographic evidence of pneumonia), moderate (pneumonia was present), severe (respiratory rate ≥30/min, or oxygen saturation ≤93% when breathing ambient air), or critical (respiratory failure requiring mechanical ventilation, shock, or organ failure requiring intensive care). We compared microbiome data with those from 6 subjects with community-acquired pneumonia and 15 healthy individuals (controls). We assessed gut microbiome profiles in association with disease severity and changes in fecal shedding of SARS-CoV-2.

Results: Patients with COVID-19 had significant alterations in fecal microbiomes compared with controls, characterized by enrichment of opportunistic pathogens and depletion of beneficial commensals, at time of hospitalization and at all timepoints during hospitalization. Depleted symbionts and gut dysbiosis persisted even after clearance of SARS-CoV-2 (determined from throat swabs) and resolution of respiratory symptoms. The baseline abundance of Coprobacillus, Clostridium ramosum, and Clostridium hathewayi correlated with COVID-19 severity; there was an inverse correlation between abundance of Faecalibacterium prausnitzii (an anti-inflammatory bacterium) and disease severity. Over the course of hospitalization, Bacteroides dorei, Bacteroides thetaiotaomicron, Bacteroides massiliensis, and Bacteroides ovatus, which downregulate expression of angiotensin-converting enzyme 2 (ACE2) in murine gut, correlated inversely with SARS-CoV-2 load in fecal samples from patients.

Conclusions: In a pilot study of 15 patients with COVID-19, we found persistent alterations in the fecal microbiome during the time of hospitalization, compared with controls. Fecal microbiota alterations were associated with fecal levels of SARS-CoV-2 and COVID-19 severity. Strategies to alter the intestinal microbiota might reduce disease severity.

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背景和目的：尽管严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 会感染胃肠组织，但对肠道共生微生物在感染易感性和严重程度方面的作用知之甚少。 我们调查了 SARS-CoV-2 感染患者在住院期间粪便微生物组的变化以及与病毒严重程度和粪便脱落的关联。

 方法：我们对 2020 年 2 月 5 日至 3 月 17 日在香港的 15 名 2019 年冠状病毒病 (COVID-19) 患者的粪便样本进行了鸟枪宏基因组测序分析。从住院开始，每周收集 2 或 3 次粪便样本 直到出院； 疾病被分类为轻度（无肺炎的放射学证据）、中度（存在肺炎）、重度（呼吸频率≥30/分钟，或呼吸环境空气时氧饱和度≤93%）或危重（呼吸衰竭需要机械通气， 休克或需要重症监护的器官衰竭）。 我们将微生物组数据与 6 名社区获得性肺炎患者和 15 名健康个体（对照组）的数据进行了比较。 我们评估了与疾病严重程度和 SARS-CoV-2 粪便排出变化相关的肠道微生物组谱。

 结果：与对照组相比，COVID-19 患者的粪便微生物组发生显着变化，其特征是在住院期间和住院期间的所有时间点，机会性病原体富集和有益共生体减少。 即使在清除 SARS-CoV-2（由咽拭子确定）和呼吸道症状消退后，耗尽的共生体和肠道菌群失调仍然存在。 Coprobacillus、Clostridium ramosum 和 Clostridium hathewayi 的基线丰度与 COVID-19 的严重程度相关； Faecalibacterium prausnitzii（一种抗炎细菌）的丰度与疾病严重程度呈负相关。 在住院期间，Bacteroides dorei、Bacteroides thetaiotaomicron、Bacteroides massiliensis 和 Bacteroides ovatus 会下调小鼠肠道中血管紧张素转换酶 2 (ACE2) 的表达，与患者粪便样本中的 SARS-CoV-2 负荷呈负相关。

 结论：在对 15 名 COVID-19 患者进行的初步研究中，我们发现与对照组相比，住院期间粪便微生物组持续发生变化。 粪便微生物群的改变与粪便中 SARS-CoV-2 和 COVID-19 的严重程度有关。 改变肠道微生物群的策略可能会降低疾病的严重程度。