Interesting presentation about false fixes and identifying addictive behaviours in our own lives. The antidote suggested is becoming more mindful of the things we use, and the intentions behind them, and just generally becoming more intentional about the habits we set up and where we source our sense of fulfillment or relief from. Neuroscience provides an interesting avenue to interpret standard understandings........Hooked, Hacked, Hijacked: Reclaim Your Brain from Addictive Living: Dr. Pamela Peeke at TEDxWallStreet
Introduction
I'm the doctor, and I'm here to save you.
(Laughter)
No, I'm not.
What I'm here to do is to fill the survival void a little differently than you've been doing for a long time.
Not everybody but lots of you are filling that survival void with what we call 'false fixes'.
And that is...
You know what I'm talking about.
I'll give you a hint: it's not apples and kale. When things get a little tough out there, it's usually that national 'ménage à trois', especially for women.
Late at night: you, Ben & Jerry.
(Laughter)
And who was it that told us that a pint of ice-cream has four servings in it?
No-no-no.
Law & Order marathon, pre-menopause, a rotten day: one serving. And there you have it! Anesthetized, ready for another day. Sounds familiar?
So, what I'm going to do is describe the problem and prescribe a little bit of a brand new solution based upon hot new science that most of you may never have heard about before.
A twist on survival. False fixes.
Well, you know how it goes. All of the false fixes we are used to in life.
I look specifically at that wine bottle,
I think about that brand new Facebook
that has an amazing following of a thousand women. It's called: "I need a glass of wine,or I'm going to sell my children."
(Laughter)
Do you think we have a problem here?
Addictive lifestyle
Look at everything else we do. You live an addictive lifestyle and you don't even know it.
It's addictive-like behaviors that happen throughout the day.
Any question about this, just give up one of those behaviors and see how it feels.
You know how it feels.
Staring at screens...
What about getting to work at five in the morning and leaving at midnight?Anything wrong with that?
What happened to eating? And what do you eat?
And do you sleep at all?
We're going to get into that.
These are what we call 'false fixes'.
Oh, sure they fix, sort of, for a short period of time, and then they boomerang right back in your face.
As we are thinking about this, what I'd like to do is take you on a journey. Mind, mouth, and muscle.
I want to go deep, and I want to show you a little bit more about these false fixes that you may not be aware of at all.
We're going to start with the mind.
Ah, the mind... It's very important...
(Laughter)
You laugh? This is highly scientific.
Now, listen up!
Men, left hemisphere, task-oriented.
Honey, you're either on or off.
Women, we're complicated. We have many knobs. That's because we, women folks, work off two hemispheres.
We have more connections between hemispheres. We spend money differently.
Men spend more money on entertainment and basically period than we do.
What do they spend it on? Booze.
Women spend it on shoes, and caregiving.
The reward center
Helping ourselves, and everyone who comes within a hundred feet of us even if we don't know them, we're caregiving them. We're eternal caregivers, to our own detriment. Keep that context in mind as we push forward.
I told you that you most probably have addictive-like behaviors, and you don't even know it. You don't even know you're filling that void with this.
I'm going to show you something you've probably never seen before.
What you're actually going to see is a PET scan, and this PET scan is extraordinary.
You have a normal brain
there's one left in the United States, but we use it a lot in these experiments -
and what you see up there is red-orange:
the red-orange of the reward center.
The reward center lights up, normally,
when dopamine - that fantastic, lustful, pleasure neurotransmitter - links up with dopamine receptors.
That's what it's supposed to look like.
Look at the other brains. It could be anything that you do.
Yes, it's not just substance abuse: it's everything abuse.
Food addiction, actually, is real.
We actually have addictive-like habits around foods.
Surprisingly, it's not kale.
This is usually hyper palatables like sugary, fatty, salty foods.
But they do a number on your brain.
You see, it's not a black box anymore. We can peer in there with scans.
What we see is the actual damage to the reward center.
Is it reversible? Absolutely.
You know exactly what you need to do.
I don't have to tell you that.
It's a keen grasp of the obvious.
Let me tell you more. Did you know that sugar is more addictive than cocaine?
Yes, refined sugar.
Lately, there was a study on Oreos that you might have heard about.
Actually, I did a nice little piece on this, and it was fabulous.
What it was: they took rats and they injected them with morphine, and they injected them with cocaine, and then they offered them an oreo.
You'll just never guess what happened.
What we were measuring was one particular gene.
We wanted to see whether or not the oreo caused the same changes as morphine and cocaine. Guess what happened.
What do you think happened?
The same thing and even worse.
Do you know that rats bagged the morphine and the cocaine and went right for the filling?
Just like you and I have done for years.
Sort of a metaphor, isn't it?
They literally - we watched them,we have videos of this -
ripping the cookie apart and going for the filling.
Yeah!
Brings back great memories.
And then more and more and more...
What's going on?
Let's look at the next part of the brainthat gets hammered with all of this.
The prefrontal cortex
As we are describing this problem, we're looking at the prefrontal cortex,
or the 'smarty-pants 'part of the brain, or on Wall Street, 'where the executive function hangs out'.
Tap your forehead,it's right behind there.
When you're living an addictive-like lifestyle with addictive-like behaviors, guess what happens.
What we notice in that scan is that the ability of the brain to be able to muster up all of the wonderful skills that you see in the prefrontal cortex, which are organizing, strategizing, staying vigilant, being mindful, reigning in impulsivity, impatience, and irritability - guess what ends up happening? - you can't do it anymore.
It gets hammered, it gets impaired,and you're out: end of story.
Not so good.
What else hammers this? Stress.
There is a reason why 'stressed' spelled backwards is 'desserts'.
Think about that.
Stress absolutely impairs this entire part of the brain.
At the same time, sleep does.
What about zzz's?
Zzz's please!
People feeling very proud of the fact
they got just four hours of sleep.
Really? Do you want a belly that extends from here to the next state?
That's a great way to do it.
Don't have enough sleep.
None of growth hormone on board when you sleep at night time, when you're impaired this way.
You have too much stress hormone, big belly. There you have it.
And that big belly is full of increased incidence of disease, morbidity, and mortality.
Who the hell needs this?
We've got to clean this up.
Let's go to the body if we're going to clean this up. Sitting disease.
You've probably never-ever heard of sitting disease.
Google it sometimes.
Mayo Clinic tells you that if you sit for too long, you increase your risk for heart disease, and more importantly, metabolically, you 'glaciarize'.
You can't move your blood sugar.
Actually, I'm a physician, this is killing me.
l want everyone to stand up. Everyone stand up!
Oh, doesn't that feel better? I'm saving your life!
If you really want to get something out of this, high-five the guy next to you.
Didn't that feel good?! Sit down!
Your genes are absolutely flipping with happiness, and at the same time I just helped to save your life.
Are you happy?
Good. Let's move it along.
Epigenetics
I know most of the guys are staring at this saying: "Yes, that's me."
(Laughter)
Women, of course, are laughing very heartily.
I told you, I'd go deep inside you: mind, mouth, muscle.
Let's go into the belly.
That's what his belly looks like if I cut him like a salami, and that's a CAT scan.
See the white in there?
You'll only see this in research.This is from our laboratory.
That's fat, not a whole lot of it.
What happens, however, when you fall asleep at the meal...
Even Michelangelo packed on a few.
Right? This is what it looks like.
What you actually see is way too much fat.
Is this reversible? Absolutely.
The guy is swimming in it right now,
and obviously, this is not the way to go.
False fixes lead to this. A life of false fixes.
Here's the solution.
How many of you ever heard about epigenetics?
Epigenetics is the hottest new science.
If you don't know it now, then make certain you know at some point.
What this is, is so straightforward.
I'm going to go right down to the gene. I'm going to show you how easy this is. For the longest period of time, we thought you were stuck with your DNA.
Whatever you're born with, honey, that was your destiny.
That's not the way it works anymore.
Instead, what we have is a brand new science that says:
every single thought you have,
every single mouthful of whatever you're eating, and every single step you take changes gene expression,
changes the way the whole body is talking to itself, and changes your destiny.
That's right: you write your own life script.
Let's see the birth of epigenetics.
Very simple.
We took a mouse that was basically condemned to death.
It had the Agouti gene deep inside it.
And this Agouti genebasically made it fat, floppy, yellow, because was a color-of-the-fur thing linked in with the Agouti gene. It died of every disease very early.
What we decided to do was just something fun.
We fed it greens - that's right, mom was right - and the greens - you didn't know -
have something called a methyl donor,
just a little side chain. It'd pick them up every single time you'd have greens and good whole foods.
At the same time, when you do physical activity, at the same time, when you meditate, the same thing is happening: you're changing gene expression.
So, we went ahead and fed the mice this.
And then they had babies.
And the babies were born lean, mean fighting machines with green.
We never knew this.
This was 2007, which is why you've probably never heard of it.
Now it's the hottest new science.
Now when you go to the produce section of the grocery store, you don't look for greens: you're cool,
because greens are so last-year.
Instead, what you actually say:"I'm going to score some methyl donors. I'm going to methylate my genes. I'm going to change their expression."
You'll be way ahead of the curve.
This is what a human being looks like when they've been methylated.
Betty Lou Sweeney: 250 pound,68 years old, 26 medications, and half dead.
And then she got the big clue- I call it an 'epipha-me' when she was stuck in an ICU, half dead.
This is what she ended up doing.
What she ended up doing was turning it all around.
She fought her food addiction.
She fought her every single addictive practice she had.
She slugged it out; it took her 2-3 years.
Guess what she ended up doing.
Ending up in the Guinness Book of World Record for holding up the longest plank.
That's right. It's 36 minutes.
Most of us can't make it beyond what?
And you don't even know what a plank is.
OK. I'm good.
Lest I forget as I wrap this up.
We need mentors. We need to know now that we could take this on to generation after generation.
We feel so good when we put mind, mouth, and muscle together. When we change gene expression. When we go epigenetic.
But there's one other piece of this too: God, you feel really good too. I met this happy camper at the Senior Olympics. He is 93 years old on the track and field, when I was covering this for television, and he taught me one other thing that you can't forget.
He stalked me for three hours. He didn't know he was 93. He thought he was 23.
Just showing you that when you go epigenetic, when you fill the void with healthy fixes, everything is looking up.
(Laughter)
He thought he was 23 years old. Just showing you that when you go epigenetic, when you fill the void with healthy fixes, everything is looking up.
(Laughter)
So, epigenetic transformation.
And do remember the last lesson:
The real wealth is health.
Thank you.
(Applause)
关于错误修复和识别我们生活中的成瘾行为的有趣演示。 建议的解药是更加关注我们使用的东西及其背后的意图，并且通常更加关注我们养成的习惯以及我们从何处获得满足感或缓解感。 神经科学为解释标准理解提供了一个有趣的途径。
......上瘾、被黑客攻击、被劫持：从上瘾的生活中夺回你的大脑：TEDxWallStreet 的 Pamela Peeke 博士
介绍
我是医生，我是来救你的。
（笑声）
不，我不是。
我来这里的目的是用与你们长期以来所做的略有不同的方式来填补生存空白。
不是每个人，但你们中的很多人都在用我们所谓的“错误修复”来填补生存空白。
那就是...
你懂我在说什么。
我给你一个提示：这不是苹果和羽衣甘蓝。 当事情变得有点艰难时，通常是全国性的“三人行”，尤其是对女性而言。
深夜：你，本和杰瑞。
（笑声）
是谁告诉我们一品脱冰淇淋有四份的？
不不不。
法律与秩序马拉松、绝经前、糟糕的一天：一份。 现在你就拥有了！ 麻醉完毕，准备迎接新的一天。 听起来很熟悉？
因此，我要做的就是描述这个问题，并根据你们大多数人以前可能从未听说过的热门新科学提出一些全新的解决方案。
生存的转折。 错误修复。
嗯，你知道事情是怎样进行的。 我们在生活中习以为常的所有错误修复。
我特意看那个酒瓶，
我想到了那个全新的 Facebook
拥有一千名女性的惊人追随者。 它的名字是：“我需要一杯酒，否则我就卖掉我的孩子。”
（笑声）
你认为我们这里有问题吗？
令人上瘾的生活方式
看看我们所做的其他一切。 你过着令人上瘾的生活方式，而你甚至不知道。
这是整天发生的类似上瘾的行为。
对此有任何疑问，只需放弃其中一种行为，看看感觉如何。
你知道那是什么感觉。
盯着屏幕...
早上五点上班，半夜下班怎么样？这样有什么问题吗？
吃饭怎么了？ 你吃什么？
你睡觉吗？
我们将深入探讨这一点。
这些就是我们所说的“错误修复”。
哦，当然，它们会在短时间内修复，然后它们就会飞回你的脸上。
当我们思考这个问题时，我想做的就是带你去旅行。 头脑、嘴巴和肌肉。
我想深入探讨，并向您展示更多有关这些您可能根本不知道的错误修复的信息。
我们将从头脑开始。
啊，心……很重要……
（笑声）
你笑？ 这是非常科学的。
现在，听着！
男性，左半球，以任务为导向。
亲爱的，你要么开启，要么关闭。
女人，我们很复杂。 我们有很多旋钮。 那是因为我们女性要使用两个半球来工作。
我们半球之间有更多的联系。 我们花钱的方式不同。
男人在娱乐和经期上比我们花更多的钱。
他们把钱花在什么地方？ 豪饮。
女性把钱花在鞋子和护理上。
奖励中心
帮助我们自己和周围一百英尺内的每个人，即使我们不认识他们，我们也在照顾他们。 我们是永远的照顾者，但这对我们自己不利。 当我们前进时，请记住这一背景。
我告诉过你，你很可能有类似上瘾的行为，而你自己却不知道。 你甚至不知道你正在用这个来填补那个空白。
我将向您展示一些您可能从未见过的东西。
您实际上将看到的是 PET 扫描，这种 PET 扫描非常出色。
你有一个正常的大脑
美国还剩下一个，但我们在这些实验中经常使用它 -
你在上面看到的是红橙色：
奖励中心的橙红色。
奖励中心正常亮起，
当多巴胺——一种奇妙的、欲望的、快乐的神经递质——与多巴胺受体连接时。
这就是它应该的样子。
看看其他人的大脑。 它可以是你所做的任何事情。
是的，这不仅仅是药物滥用：一切都是滥用。
事实上，食物成瘾是真实存在的。
事实上，我们对食物有类似上瘾的习惯。
令人惊讶的是，这不是羽衣甘蓝。
这些通常是非常美味的食物，如糖、脂肪和咸的食物。
但它们会对你的大脑产生一些影响。
你看，它不再是一个黑匣子了。 我们可以通过扫描查看那里。
我们看到的是奖励中心的实际损坏。
是可逆的吗？ 绝对地。
你清楚地知道你需要做什么。
我不必告诉你这一点。
这是对显而易见的事物的敏锐把握。
让我告诉你更多。 您知道糖比可卡因更容易上瘾吗？
是的，精制糖。
最近，您可能听说过一项关于奥利奥的研究。
事实上，我在这方面做了一个很好的小作品，非常棒。
事情是这样的：他们给老鼠注射吗啡，给它们注射可卡因，然后给它们一块奥利奥。
你永远猜不到发生了什么。
我们测量的是一种特定的基因。
我们想看看奥利奥是否会引起与吗啡和可卡因相同的变化。 猜猜发生了什么。
你认为发生了什么？
这是同样的事情，甚至更糟。
你知道老鼠把吗啡和可卡因装进袋子里然后直接去填充吗？
就像你和我多年来所做的那样。
有点比喻，不是吗？
他们确实 - 我们看过他们，我们有这方面的视频 -
把饼干撕开，然后去填充。
是的！
带回美好的回忆。
然后越来越多、越来越多……
这是怎么回事？
让我们看看大脑中受到所有这些影响的下一个部分。
前额皮质
当我们描述这个问题时，我们正在研究前额皮质，
或者是大脑中“自作聪明”的部分，或者在华尔街，“执行功能发挥作用的地方”。
轻拍你的额头，它就在后面。
当你过着令人上瘾的生活方式和令人上瘾的行为时，猜猜会发生什么。
我们在扫描中注意到，大脑有能力聚集你在前额皮质中看到的所有奇妙技能，这些技能是组织、制定战略、保持警惕、留心、控制冲动、不耐烦、 和烦躁——猜猜最后会发生什么？ - 你不能再这样做了。
它受到重击，受到损害，然后你就出局了：故事结束了。
不太好。
还有什么可以打击这个？ 压力。
“stressed”倒过来拼写为“desserts”是有原因的。
考虑一下。
压力绝对会损害大脑的整个部分。
与此同时，睡眠也是如此。
那么zzz呢？
Zzz，拜托了！
人们对此感到非常自豪
他们只睡了四个小时。
真的吗？ 你想要一个从这里延伸到下一个状态的肚子吗？
这是一个很好的方法。
睡眠不够。
当你晚上睡觉时，当你受到这种方式的损害时，船上就没有生长激素了。
你压力太大——荷尔蒙，大肚子。 你有它。
这个大肚子里装满了不断增加的疾病发生率、发病率和死亡率。
谁到底需要这个？
我们必须把它清理干净。
如果我们要清理的话，就去尸体吧。 坐病。
您可能从未听说过久坐症。
有时谷歌一下。
梅奥诊所告诉您，如果坐得太久，您患心脏病的风险就会增加，更重要的是，从新陈代谢的角度来看，您会“冰川化”。
你无法改变你的血糖。
事实上，我是一名医生。 这简直要了我的命。
我希望每个人都站起来。 大家都站起来！
哦，这样是不是感觉好多了？ 我正在救你的命！
如果你真的想从中得到一些东西，就向你旁边的人击掌吧。
是不是感觉很好？！ 坐下！
你的基因绝对会因为幸福而翻转，同时，我刚刚帮助拯救了你的生命。
你快乐吗？
好的。 让我们一起移动它。
表观遗传学 Biǎo guān yíchuán xué
我知道大多数人都盯着这句话：“是的，那就是我。” wǒ zhīdào dà duōshù rén dōu dīngzhe zhè jù huà:“Shì de, nà jiùshì wǒ.”
（笑声）(Xiào shēng)
女人当然笑得很开心。
我告诉过你，我会深入你的内心：思想、嘴巴、肌肉。
我们进入肚子吧。
如果我像切萨拉米香肠一样切开他，他的腹部就是这个样子，这是 CAT 扫描。
看到里面的白色了吗？
您只会在研究中看到这一点。这是来自我们的实验室。
那是脂肪，不是很多。
然而，当你在吃饭时睡着时会发生什么......
就连米开朗基罗也带了一些。
正确的？ 这就是它的样子。
你实际上看到的是太多的脂肪。
这是可逆的吗？ 绝对地。
那家伙现在正在里面游泳，
显然，这不是正确的方法。
错误的修复会导致这种情况。 错误修复的一生。
这是解决方案。
你们中有多少人听说过表观遗传学？
表观遗传学是最热门的新科学。
如果您现在不知道，那么请确保您在某个时候知道。
这是什么，非常简单。
我要直接讲到基因。 我将向您展示这是多么容易。 在最长的一段时间里，我们认为你被自己的 DNA 困住了。
无论你生来就有什么，亲爱的，那都是你的命运。
现在已经不再是这样了。
相反，我们拥有的是一门全新的科学，它说：
你的每一个想法，
你吃的每一口，你采取的每一步都会改变基因表达，
改变整个身体自言自语的方式，并改变你的命运。
没错：你编写自己的人生剧本。
让我们看看表观遗传学的诞生。
很简单。
我们拿了一只基本上被判死刑的老鼠。
它的深处有刺豚鼠基因。
这种刺豚鼠基因基本上让它变得又肥又软又黄，因为它是一种与刺豚鼠基因相关的毛皮颜色。 它很早就死于各种疾病。
我们决定做的只是一些有趣的事情。
我们喂它绿色蔬菜 - 是的，妈妈是对的 - 而绿色蔬菜 - 你不知道 -
有一种叫做甲基供体的东西
只是一点侧链。 每当你吃到蔬菜和优质天然食品时，它就会把它们捡起来。
Wǒ yào zhíjiē jiǎng dào jīyīn. Wǒ jiāng xiàng nín zhǎnshì zhè shì duōme róngyì. Zài zuì zhǎng de yīduàn shíjiān lǐ, wǒmen rènwéi nǐ bèi zìjǐ de DNA kùn zhùle.
Wúlùn nǐ shēnglái jiù yǒu shé me, qīn'ài de, nà dōu shì nǐ de mìngyùn.
Xiànzài yǐjīng bù zài shì zhèyàngle.
Xiāngfǎn, wǒmen yǒngyǒu de shì yī mén quánxīn de kēxué, tā shuō:
Nǐ de měi yīgè xiǎngfǎ,
nǐ chī de měi yīkǒu, nǐ cǎiqǔ de měi yībù dūhuì gǎibiàn jīyīn biǎodá,
gǎibiàn zhěnggè shēntǐ zì yán zì yǔ de fāngshì, bìng gǎibiàn nǐ de mìngyùn.
Méi cuò: Nǐ biānxiě zìjǐ de rénshēng jùběn.
Ràng wǒmen kàn kàn biǎo guān yíchuán xué de dànshēng.
Hěn jiǎndān.
Wǒ men nále yī zhǐ jīběn shàng bèi pàn sǐxíng de lǎoshǔ.
Tā de shēn chù yǒu cì túnshǔ jīyīn.
Zhè zhǒng cì túnshǔ jīyīn jīběn shàng ràng tā biàn dé yòu féi yòu ruǎn yòu huáng, yīnwèi tā shì yī zhǒng yǔ cì túnshǔ jīyīn xiāngguān de máopí yánsè. Tā hěn zǎo jiù sǐ yú gè zhǒng jíbìng.
Wǒ men juédìng zuò de zhǐshì yīxiē yǒuqù de shìqíng.
Wǒmen wèi tā lǜsè shūcài - shì de, māmā shì duì de - ér lǜsè shūcài - nǐ bù zhīdào -
yǒuyī zhǒng jiàozuò jiǎ jī gōng tǐ de dōngxī
zhǐshì yīdiǎn cè liàn. Měi dāng nǐ chī dào shūcài hé yōuzhì tiānrán shípǐn shí, tā jiù huì bǎ tāmen jiǎn qǐlái.
与此同时，当你进行体力活动时，同时当你冥想时，同样的事情正在发生：你正在改变基因表达。Yǔ cǐ tóngshí, dāng nǐ jìnxíng tǐlì huódòng shí, tóngshí dāng nǐ míngxiǎng shí, tóngyàng de shìqíng zhèngzài fāshēng: Nǐ zhèngzài gǎibiàn jīyīn biǎodá.
所以，我们继续给老鼠喂这个。
然后他们有了孩子。
而且婴儿出生时身材瘦削，意味着带有绿色的战斗机器。
我们从来不知道这一点。
那是 2007 年，这就是为什么你可能从未听说过它。
Suǒyǐ, wǒ men jìxù gěi lǎoshǔ wèi zhège.
Ránhòu tā men yǒule háizi.
Érqiě yīng'ér chūshēng shí shēncái shòuxuē, yìwèizhe dài yǒu lǜsè de zhàndòujī qì.
Wǒ men cónglái bu zhīdào zhè yīdiǎn.
Nà shì 2007 nián, zhè jiùshì wèishéme nǐ kěnéng cóng wèi tīng shuōguò tā.
现在它是最热门的新科学。Xiànzài tā shì zuì rèmén de xīn kēxué.
现在，当你去杂货店的农产品区时，你不会寻找蔬菜：你很酷，
因为去年的蔬菜太新鲜了。Xiànzài, dāng nǐ qù záhuò diàn de nóngchǎnpǐn qū shí, nǐ bù huì xúnzhǎo shūcài: Nǐ hěn kù,
yīnwèi qùnián de shūcài tài xīnxiānle.
相反，你实际上说的是：“我要获得一些甲基供体。我要甲基化我的基因。我要改变它们的表达。” Xiāngfǎn, nǐ shíjì shang shuō de shì:“Wǒ yào huòdé yīxiē jiǎ jī gōng tǐ. Wǒ yào jiǎ jī huà wǒ de jīyīn. Wǒ yào gǎibiàn tāmen de biǎodá.”
您将远远领先。Nín jiāng yuǎn yuǎn lǐngxiān.
这就是人类被甲基化后的样子。Zhè jiùshì rénlèi bèi jiǎ jī huà hòu de yàngzi.
Betty Lou Sweeney：250磅，68岁，服药26次，半死不活。
然后她得到了一个重要线索——当她半死不活地被困在重症监护室时，我称之为“epipha-me”。
这就是她最终所做的。
她最终所做的就是扭转这一切。
她与食物成瘾作斗争。
她与自己的每一种成瘾行为作斗争。
她奋力一搏； 她花了2-3年的时间。
猜猜她最后做了什么。
因举起最长的木板而被载入吉尼斯世界纪录。
这是正确的。 已经36分钟了。
我们大多数人都无法超越什么？
而且你甚至不知道平板支撑是什么。
好的。 我很好。
以免我在结束时忘记。
我们需要导师。 我们现在需要知道我们可以将这一点代代相传。
Betty Lou Sweeney:250 Bàng,68 suì, fúyào 26 cì, bànsǐbùhuó.
Ránhòu tā dédàole yīgè zhòngyào xiànsuǒ——dāng tā bànsǐbùhuó dì bèi kùn zài zhòngzhèng jiānhù shì shí, wǒ chēng zhī wèi “epipha-me”.
Zhè jiùshì tā zuìzhōng suǒ zuò de.
Tā zuìzhōng suǒ zuò de jiùshì niǔzhuǎn zhè yīqiè.
Tā yǔ shíwù chéng yǐn zuò dòuzhēng.
Tā yǔ zìjǐ de měi yī zhǒng chéng yǐn xíngwéi zuò dòuzhēng.
Tā fènlì yī bó; tā huāle 2-3 nián de shíjiān.
Cāi cāi tā zuìhòu zuòle shénme.
Yīn jǔ qǐ zuì zhǎng de mùbǎn ér bèi zài rù jí nísī shìjiè jìlù.
Zhè shì zhèngquè de. Yǐjīng 36 fēnzhōngle.
Wǒmen dà duōshù rén dōu wúfǎ chāoyuè shénme?
Érqiě nǐ shènzhì bù zhīdào píngbǎn zhīchēng shì shénme.
Hǎo de. Wǒ hěn hǎo.
Yǐmiǎn wǒ zài jiéshù shí wàngjì.
Wǒmen xūyào dǎoshī. Wǒmen xiànzài xūyào zhīdào wǒmen kěyǐ jiāng zhè yīdiǎn dài dài xiāngchuán.
当我们将头脑、嘴巴和肌肉结合在一起时，我们感觉非常好。 当我们改变基因表达时。 当我们进行表观遗传时。Dāng wǒmen jiāng tóunǎo, zuǐbā hé jīròu jiéhé zài yīqǐ shí, wǒmen gǎnjué fēicháng hǎo. Dāng wǒmen gǎibiàn jīyīn biǎodá shí. Dāng wǒmen jìnxíng biǎo guān yíchuán shí.
但还有另一件事：上帝，你也感觉很好。 我在高级奥运会上遇到了这位快乐的营员。 当我在电视上报道这一点时，他已经 93 岁了，在田径场上，他教会了我另一件事，你不能忘记。Dàn hái yǒu lìng yī jiàn shì: Shàngdì, nǐ yě gǎnjué hěn hǎo. Wǒ zài gāojí àoyùnhuì shàng yù dàole zhè wèi kuàilè de yíng yuán. Dāng wǒ zài diànshì shàng bàodào zhè yīdiǎn shí, tā yǐjīng 93 suìle, zài tiánjìng chǎng shàng, tā jiàohuìle wǒ lìng yī jiàn shì, nǐ bùnéng wàngjì.
他跟踪了我三个小时。 他不知道自己已经93岁了。他以为自己23岁了。Tā gēnzōngle wǒ sān gè xiǎoshí. Tā bù zhīdào zìjǐ yǐjīng 93 suìle. Tā yǐwéi zìjǐ 23 suìle.
我只是向你展示，当你进行表观遗传，当你用健康的修复来填补空白时，一切都会好起来的。
（笑声）Wǒ zhǐshì xiàng nǐ zhǎnshì, dāng nǐ jìnxíng biǎo guān yíchuán, dāng nǐ yòng jiànkāng de xiūfù lái tiánbǔ kòngbái shí, yīqiè dūhuì hǎo qǐlái de.
(Xiào shēng)
他以为自己已经23岁了。 我只是向你展示，当你进行表观遗传，当你用健康的修复来填补空白时，一切都会好起来的。
（笑声）
tā yǐwéi zìjǐ yǐjīng 23 suìle. Wǒ zhǐshì xiàng nǐ zhǎnshì, dāng nǐ jìnxíng biǎo guān yíchuán, dāng nǐ yòng jiànkāng de xiūfù lái tiánbǔ kòngbái shí, yīqiè dūhuì hǎo qǐlái de.
(Xiào shēng)
因此，表观遗传转化。
请记住最后一课：
真正的财富是健康。
谢谢。
（掌声）
yīncǐ, biǎo guān yíchuán zhuǎnhuà.
Qǐng jì zhù zuìhòu yī kè:
Zhēnzhèng de cáifù shì jiànkāng.
Xièxiè.
What Genes Cannot Tell: The role of epigenetics in determining who we are.
All the cells in our body have the same DNA, and yet a stomach cell is able to digest food while a heart cell pumps blood. Similarly, genetically identical individuals have the same DNA, yet they develop into unique individuals with distinct habits, preferences, and behavioral traits. Clearly there is more to us than just our genetic makeup. This additional layer of information is defined by epigenetics, which literally means “above genetics”. Our lifestyle, habits and environment shape our epigenetics, which is altered throughout our lifetime and can be passed to our future generations. Epigenetic factors have been shown to play a role in diseases like cancer, obesity, and diabetes. We will demonstrate how these epigenetic factors may be inherited and their potential impact on the future generation. In this lecture, we will tell stories demonstrating the role epigenetics plays in our daily lives, the biology behind epigenetics, and its implication on human health and disease.
我们体内的所有细胞都具有相同的 DNA，但胃细胞能够消化食物，而心脏细胞则能够泵血。 同样，基因相同的个体具有相同的 DNA，但他们会发展成为具有不同习惯、偏好和行为特征的独特个体。 显然，我们不仅仅是基因构成。 这一额外的信息层由表观遗传学定义，字面意思是“高于遗传学”。 我们的生活方式、习惯和环境塑造了我们的表观遗传学，而表观遗传学在我们的一生中都会发生改变，并且可以遗传给我们的后代。 表观遗传因素已被证明在癌症、肥胖和糖尿病等疾病中发挥作用。 我们将展示这些表观遗传因素如何遗传及其对下一代的潜在影响。 在本次讲座中，我们将讲述一些故事，展示表观遗传学在我们日常生活中的作用、表观遗传学背后的生物学及其对人类健康和疾病的影响。
● Wǒ men tǐ nèi de suǒ yǒu xì bāo dōu jù yǒu xiāng tóng de DNA, dàn wèi xì bāo néng gòu xiāo huà shí wù, ér xīn zàng xì bāo zé néng gòu bèng xuè. Tóngyàng, jīyīn xiāngtóng de gètǐ jùyǒu xiāngtóng de DNA, dàn tāmen huì fāzhǎn chéngwéi jùyǒu bùtóng xíguàn, piānhào hé xíngwéi tèzhēng de dútè gètǐ. Xiǎnrán, wǒmen bùjǐn jǐn shì jīyīn gòuchéng. Zhè yī éwài de xìnxī céng yóu biǎo guān yíchuán xué dìngyì, zìmiàn yìsi shì “gāo yú yíchuán xué”. Wǒmen de shēnghuó fāngshì, xíguàn hé huánjìng sùzàole wǒmen de biǎo guān yíchuán xué, ér biǎo guān yíchuán xué zài wǒmen de yīshēng zhōng dūhuì fāshēng gǎibiàn, bìngqiě kěyǐ yíchuán gěi wǒmen de hòudài. Biǎo guān yíchuán yīnsù yǐ bèi zhèngmíng zài áizhèng, féipàng hé tángniàobìng děng jíbìng zhōng fāhuī zuòyòng. Wǒmen jiāng zhǎnshì zhèxiē biǎo guān yíchuán yīnsù rúhé yíchuán jí qí duì xià yīdài de qiánzài yǐngxiǎng. Zài běn cì jiǎngzuò zhōng, wǒmen jiāng jiǎngshù yīxiē gùshì, zhǎnshì biǎo guān yíchuán xué zài wǒmen rìcháng shēnghuó zhōng de zuòyòng, biǎo guān yíchuán xué bèihòu de shēngwù xué jí qí duì rénlèi jiànkāng hé jíbìng de yǐngxiǎng.
