Sweet potatoes leaves

 The Eden Prescription.

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Sweet Potato Leaves (Cantonese: fun she yip) Kills 94% of Prostate Cancer Cells in Vitro. 

An extract of sweet potato leaves was discovered to be extremely toxic to prostate cancer cells in this study, killing 94% of them in vitro & slowing the growth of prostate tumors in mice by 75%.

 Other research has shown that these super-greens are also active against breast cancer, lung cancer, colon cancer, stomach cancer & leukemia. 

And the health benefits of these greens are not just for the lab. One study in Taiwan showed that eating at least 100 grams per week of this super vegetable decreased lung cancer risk by up to 57%!

 In other studies, sweet potato leaves boosted immunity (T-lymphocytes & natural killer cells) in humans & lowered blood sugar in mice with Type II diabetes.

 And if you need an energy boost, sweet potato leaves could be just the vegetable for you. 

A recent study showed it significantly relieved fatigue in mice, increased exercise capacity & even boosted muscle glycogen levels!

 Why are these greens so powerful? They are an excellent source of potent antioxidants called polyphenols, including the unique & powerful caffeoylquinic acids, & anti-cancer peptides.

 And alkaline diet fans take note: these greens are one of the most alkalizing vegetables out there, delivering 400% of the alkalizing power of pure lemon juice, ounce for ounce.

#SweetPotato #ProstateCancer #Greens #Alkalizing

http://www.ncbi.nlm.nih.gov/pubmed/23629419

伊甸园处方。

 红薯叶（粤语：fun she yip）在体外杀死 94% 的前列腺癌细胞。 在这项研究中，发现红薯叶提取物对前列腺癌细胞有剧毒，可在体外杀死 94% 的癌细胞，并使小鼠前列腺肿瘤的生长减缓 75%。 其他研究表明，这些超级蔬菜对乳腺癌、肺癌、结肠癌、胃癌和白血病也有活性。 这些绿色蔬菜的健康益处不仅仅适用于实验室。 台湾的一项研究表明，每周至少吃 100 克这种超级蔬菜，可将肺癌风险降低高达 57%！ 在其他研究中，红薯提高了人类的免疫力（T 淋巴细胞和自然杀伤细胞），并降低了 II 型糖尿病小鼠的血糖。 如果你需要能量提升，红薯叶可能只是你的蔬菜。 最近的一项研究表明，它显着缓解了小鼠的疲劳，增加了运动能力，甚至提高了肌糖原水平！ 为什么这些绿色植物如此强大？ 它们是称为多酚的强效抗氧化剂的极好来源，包括独特而强大的咖啡酰奎尼酸和抗癌肽。 碱性饮食爱好者请注意：这些蔬菜是最碱化的蔬菜之一，可提供纯柠檬汁 400% 的碱化能力，一盎司一盎司。

Polar biophenolics in sweet potato greens extract synergize to inhibit prostate cancer cell proliferation and in vivo tumor growth

Polyphenolic phytochemicals present in fruits and vegetables indisputably confer anticancer benefits upon regular consumption. Recently, we demonstrated the growth-inhibitory and apoptosis-inducing properties of polyphenol-rich sweet potato greens extract (SPGE) in cell culture and in vivo prostate cancer xenograft models. However, the bioactive constituents remain elusive. Here, we report a bioactivity-guided fractionation of SPGE based upon differential solvent polarity using chromatographic techniques that led to the identification of a remarkably active polyphenol-enriched fraction, F5, which was ~100-fold more potent than the parent extract as shown by IC50 measurements in human prostate cancer cells. High-performance liquid chromatography-ultraviolet and mass spectrometric analyses of the seven SPGE fractions suggested varying abundance of the major phenols, quinic acid (QA), caffeic acid, its ester chlorogenic acid, and isochlorogenic acids, 4,5-di-CQA, 3,5-di-CQA and 3,4-di-CQA, with a distinct composition of the most active fraction, F5.

 Subfractionation of F5 resulted in loss of bioactivity, suggesting synergistic interactions among the constituent phytochemicals. Quantitative analyses revealed a ~2.6- and ~3.6-fold enrichment of QA and chlorogenic acid, respectively, in F5 and a definitive ratiometric relationship between the isochlorogenic acids. Daily oral administration of 400mg/kg body wt of F5 inhibited growth and progression of prostate tumor xenografts by ~75% in nude mice, as evidenced by tumor volume measurements and non-invasive real-time bioluminescence imaging. These data generate compelling grounds to further examine the chemopreventive efficacy of the most active fraction of SPGE and suggest its potential usefulness as a dietary supplement for prostate cancer management.

Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids.

 Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vegetables including spinach. 

The polyphenol-rich SPGE exerts significant antiproliferative activity in a panel of prostate cancer cell lines while sparing normal prostate epithelial cells.

 Mechanistically, SPGE perturbed cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo. 

SPGE-induced apoptosis has a mitochondrially mediated component, which was attenuated by pretreatment with cyclosporin A. 

We also observed alterations of apoptosis regulatory molecules such as inactivation of Bcl2, upregulation of BAX, cytochrome c release and activation of downstream apoptotic signaling. 

SPGE caused DNA degradation as evident by terminal deoxynucleotidyl transferase-mediated dUTP-nick-end labeling (TUNEL) staining of increased concentration of 3'-DNA ends.

 Furthermore, apoptotic induction was caspase dependent as shown by cleavage of caspase substrate, poly (adenosine diphosphate-ribose) polymerase.

 Oral administration of 400 mg/kg SPGE remarkably inhibited growth and progression of prostate tumor xenografts by ∼69% in nude mice, as shown by tumor volume measurements and non-invasive real-time bioluminescent imaging. Most importantly, SPGE did not cause any detectable toxicity to rapidly dividing normal tissues such as gut and bone marrow.

 This is the first report to demonstrate the in vitro and in vivo anticancer activity of sweet potato greens in prostate cancer.