Showing posts with label human. Show all posts
Showing posts with label human. Show all posts

Thursday, October 26, 2017

The Process and Effects of Human Body Dehydration

Most people have experienced the dry mouth or slight twinge of a headache that usually signals the need for fresh water, but few people are aware of the actual process that takes us to the point of dehydration. It all starts with the hypothalamus, the gland responsible for a number of functions, including:
~ Hormone production.
~ Body temperature regulation.
~ Constant evaluation and maintenance of the human body's fluid balance.
Image result for hypothalamus

  All three of these functions play roles in the process of keeping the body hydrated. When the hypothalamus detects too little water in the blood, it signals to the pituitary gland to release an anti-diuretic hormone (ADH).

Image result for pituitary gland

Image result for pituitary gland

The ADH signals the kidneys to minimize their process of removing water from the blood while returning as much fluid as possible into the bloodstream. Once the kidneys pump the brakes on water extraction and instead focus on returning water content to the blood, the need to urine lessens and urine becomes more concentrated, thus the darker yellow hue that is a common indicator of dehydration. Once this process has reached a point where the blood volume is adversely affected, the brain signals thirst, and you feel the urge to drink water. Note that the first thirst signal was triggered when the body is already 2 percent dehydrated. If the process is prolonged, when you do not drink any fresh water right away, the percentage of water in the blood drops, leading to a reduced blood volume, this in turn leads to a drop in blood pressure and an increase in heart rate, both of which are detrimental to all of the cells, as well as the organs and systems throughout the human body.
As the process of becoming dehydrated continues to pile stress on the cardiovascular system, the supply and delivery to the brain is reduced, resulting in headaches, fatigue, inability to concentrate, sleepy, and fluctuations in mood. Once enough fresh water is consumed, though, the body is able to replenish the blood, cells, organs, and systems with the hydration they require, the human body can function as intended again.

Sunday, October 22, 2017

HOW TO DEAL WITH BACK PAIN & RHEUMATOID JOINT PAIN.

How to Deal with Your Back Pain and Rheumatoid Joint Pain: A Preventive and Self Treatment......

 About the Author
  Dr. Fereydoon Batmanghelidj ( "Batman-ge-lij" ー who did not wish to be licensed for "practice of pharmaceutically oriented and invasive medicine in the U.S.") received formal medical training at St. mary'd Hospital Medical School (London University). He research into the phenomenon of pain and water metabolism of the human body has dictated a paradigm change in the basic understanding of science applied to the practice of medicine. His views are published in scientific journals. The underlying principles of the recommendations in his treatment procedures are the most current knowledge of anatomy and the science of physiology.
    Since a highly significant and basic paradigm change is the practice of medicine, in the face of very stiff commercial and professional resistance, will be difficult to institute unless there is a concurrent public educational program to force the change, it has become necessary to begin a highly coordinated public awareness program. The author believes: " To end major diseases in earth within two decades is now a possibility. A paradigm change in the science of medicine will do it, but the public must demand the change. the time to act is now." - 1991, F. Batmanghelidj.

  For production of educational materials for public, under legal advisement, it became necessary to establish Global Health Solutions Inc.*, a legally independent enterprise. This self-treatment manual, How to Deal Simply with Back Pain & Rheumatoid Joint Pain, and the videotape How to Deal with Back Pain  are the first of these educational products. 


*NOTE: About Us: Global Health Solutions
Global Health Solutions, GHS, a worldwide publishing house, founded and developed by F. Batmagnhelidj, M.D., the world's foremost medical researcher on the medical properties of water, is a center of education for those who prefer to adhere to the logic of the natural and the simple in medicine.
GHS is dedicated to spreading the information of new science in medicine and promoting the public awareness of the hidden wonders of natural, simple, pure water in improving the public health and well-being.
GHS publishes Dr. F. Batmanghelidj¡'s pioneering work on dehydration that identifies different health problems caused by persistent dehydration of the human body - a totally different perspective to the cause and cure of many human diseases until now thought to be incurable.
Dr. B's two decades of research revealed a simple truth that unintentional chronic dehydration can cause diseases; it also demonstrated that many of the chronic degenerative diseases are preventable, and some of them can even be cured by increasing daily water intake. Dr. B's groundbreaking work provides new knowledge and new possibilities for improving and maintaining good health that the public need and deserve to know.
GHS is proud to be the publisher of all of Dr. B's six books in the series of You're Not Sick, You're Thirsty, as well as some of his most informative and inspiring public lectures and seminars in audio-visual formats.
GHS is committed to fulfilling Dr. B's mission - a mission to educate the public about the truth of dehydration so that we will not become unnecessarily over-drugged; to promote the public awareness of the healing powers of water so that we can become healers of our own bodies; to transform the expensive sick-care system so that we can have a more nature-friendly, people-friendly health care system.

LOOK INSIDE THE BOOK, CLICK HERE

How to Deal with Back Pain and Rheumatoid Joint Pain is a practical manual based on the author's many years of research and numerous clinical observations. The book introduces a new medical technology to treat and prevent back pain and rheumatoid joint pain. 

* Learn the vital information on the mechanics behind your spinal column, the role of the disc and its needs for water. 

* Learn the simple body movement that will promote fluid circulation in the disc spaces that will result in relief of the back pain and sciatic pain. 

* It is simple, safe and inexpensive. 

Don't hate yourself for missing out on this information.

The Cell
Let us take a  look at the most basic life-generating element in the human body, the cell. The cell is  surrounded by a very thin outer "skin" or membrane that protects it from being flooded by unregulated entry of water, salt, sugar, fats and many other elements that constitute the serum solution that is outside the cell wall.
  Since the cell is constantly bathed in serum solution, it regulates its intake and output by means of many, many small pumping units. Fluid inside the cells should be neutral, neither too acidic nor too alkaline; it has a pH of 7.4 under normal circumstance. The way this neutral pH maintained is very simple : the cation (cat-i-on) pumps constantly pump out hydrogen ion, which is the acid substance not used by the cell. The entire human body ー nerve tissue, bone, cartilage, ligament, muscle, blood, brain, you name it ー is made up of these tiny cells, each performing this regulation of intake and output of elements to maintain function. Each cell is just like an underwater city, with canal systems and waterways; outside of it, arteries and veins are its highways. 

Tuesday, October 3, 2017

GETTING IN SYNC

Vitamin G : The Lost Supplement ..63 (click to read)

GETTING IN SYNC
Our dogs Pumpkin and Sawa (and our new wonder cat, Bam Bam) always wanted their food at exactly the same time everyday. But how did they know it was time to eat? They were not wearing puppy watches or kitty watches, but their internal clocks told the, when to wake, sleep, and even salivate for food. All animals except for humans, with our artificial light, computer screens, and TVs, have synchronized their body clocks with that of the earth. But by exercising regularly, particularly barefoot and feeling the ground, we can reconnect with and reset our internal clocks.

  Once you are ready and prepped to go barefoot walking, we recommend walking outside on a regular basis, particularly at sunrise, (best at 8A.M.), and sunset, (best at 5P.M.). Whatever hour of the day you choose, at your convenience , try to go outdoor every day at the same time. The human body will learn when to rise and when to sleep, when to think, and when to go quiet. This body knowledge helps us let go, relax, and get in sync with the earth.

THE PHYSICS OF GETTING GROUNDED

Getting grounded is not merely a spiritual feeling; it has its roots in physics.

  Since the beginning of time, we humans have walked, slept, and spent most of our time with our bare feet on the ground, unaware that this physical direct contact transfers natural healing, electrical energy to our bodies. 

  For the first time in history, our modern lifestyle has disconnected us from the earth's energy , making us more vulnerable to stress and illness. We wear insulating rubber-soled or synthetic-soled shoes, travel around in metal boxes with insulating rubber wheels, and eat, sleep, and work in structures raised above the ground. New research, spearheaded by Clint Ober, is showing that when we reconnect to the earth by way of our bare feet, or by using a grounding device, a myriad of things happen to support health and vitality.

Grounding Helps Thin Dangerously Thick Blood and Fights Inflammation and Disease
Story at-a-glance
When you walk barefoot, free electrons are transferred from the earth into your body, and this grounding effect is one of the most potent antioxidants we know of.
Inflammation thrives when your blood is thick, and you have a lot of free radical stress, and a lot of positive charges in your body. Grounding effectively alleviates inflammation because it thins your blood and infuses you with negatively charged ions through the soles of your feet.
Surfaces that allow for proper grounding include sand, grass, bare dirt, and untreated concrete, brick and ceramic tile. Leather-soled shoes also allow you to ground while walking, whereas rubber-soled shoes disconnect you from the earth and block beneficial electron transfer.
Grounding helps thin your blood by improving its zeta potential, which means it improves the energy between your red blood cells. Research has demonstrated it takes about 80 minutes for the free electrons from the earth to reach your blood stream and transform your blood.
⇿Grounding is contraindicated if you take Coumadin, as it may thin your blood too much.


By Dr. Mercola

Dr. Stephen Sinatra is a prominent cardiologist and an innovative pioneer. He promotes a number of natural strategies as "add-ons" to the field of cardiology, such as grounding or earthing, which is the topic of this interview.

He'd done five years of post-graduate training in conventional medicine when, in 1977, he met Dr. Jacob Rinse, a 91-year old Dutch chemist who exposed him to alternative medicine.

"After that I studied some nutrition," he says, "but I became a psychotherapist. I spent 10 years training in psychotherapy. I studied bioenergetic psychotherapy, which looks at energy blocks in the body.

That really helped launch me even more into alternative medicine. Then I decided that nutrition needed more work, so I studied for the American College of Nutrition exam, a test to certify a nutrition specialist."

Then, 10 years ago, he met Clint Ober, who introduced him to grounding. (Ober is the co-author with Dr. Sinatra of the 2010 book, Earthing: The Most Important Health Discovery Ever?).

"At first I was skeptical," Dr. Sinatra admits.

"I said, 'My gosh, putting my feet on the ground is going to improve my heart, my body; or at least the things that Clint is talking about?' But then... I spoke to him for about an hour, and went from skeptical to being all in! ... [L]ook, the heart is the most electrical organ of the body. We are electrical [beings]."

What Is Earthing?
The terms "earthing" and "grounding" are interchangeable. It is simply the act of placing your bare feet on the earth, or walking barefoot. When you do, free electrons are transferred from the earth into your body, and this grounding effect is one of the most potent antioxidants we know of.

Unfortunately, few people ever walk barefoot anymore to experience it.

Hopefully, as more and more people become aware of the importance of being grounded, this will change, or at the very least spawn a much needed change in the way most footwear is made. Synthetic rubber soles disconnect you from the earth. Leather soles do not. So you can still find shoes that allow you to remain grounded without going barefoot.

Grounding has numerous benefits, aside from creating a general feeling of well-being. For example, walking barefoot can help ameliorate the constant assault of electromagnetic fields and other types of radiation from cell phones, computers and Wi-Fi. 

By getting outside, barefoot, touching the earth, and allowing the excess charge in your body to discharge into the earth, you can alleviate some of the stress put on your system. That is the grounding effect. I have personally prioritized grounding myself to the earth as much as possible for over 5 years.

Inflammation -- The Root of Most Disease

One of the primary health benefits of grounding is its antioxidant effect. It helps alleviate inflammation throughout your body.

"I told [Clint Ober] 10 years ago, "What you need to do is show that grounding improves inflammation. If you can show that, then you can show that it improves heart disease. Because the real cause of heart disease is inflammation. It's not cholesterol like everybody believes. It's really inflammation," Dr. Sinatra says. ... [H]is experimental work was just really awesome, and I got involved with research myself. I'm still smack in the middle of it right now, but it took me 10 years."

Dr. Sinatra goes on to tell the inspiring story of a contractor he met about 23 years ago, who at one point worked with a group of Scandinavian carpenters who really understood the benefits of grounding and supported each other in maintaining this healthy habit:

"They all took off their shoes in the morning and walked barefoot on the wet grass," he says. "He came to work as a young carpenter, and the foreman said to him, 'Hey buddy, you better take your shoes off, because if you come to work right now with those shoes on, you're going to be busted up in 10 years. Your joints are going to be aching. Your muscles are going to be aching. Everything's going to be aching...' He told him to take his shoes off for an hour in the morning. Guys slugging sledgehammers, digging and hammering. It's stress to the tissues. But if they put their feet on the ground for an hour and had their coffee breaks with their shoes off, it made a difference."

According to Dr. Sinatra, inflammation thrives when your blood is thick and you have a lot of free radical stress, and a lot of positive charges in your body. Grounding effectively alleviates inflammation because it thins your blood and infuses you with negatively charged ions through the soles of your feet. But beware; not all surfaces allow you to ground.

What Surfaces Will Allow You to Properly Ground?
Good grounding surfaces include:

•Sand (beach)
•Grass (preferably moist)
•Bare soil
•Concrete and brick (as long as it's not painted or sealed)
•Ceramic tile


The following surfaces will NOT ground you:

•Asphalt
•Wood
•Rubber and plastic
•Vinyl
•Tar or tarmac

An interesting tidbit offered by Dr. Sinatra is how to ground while flying. I typically bring a grounding pad with me when I fly, but Dr. Sinatra claims that simply taking your shoes off and putting your feet (bare or with socks) on the steel struts will do the trick.

The Earth Is a Rich Source of Healthful Electrons

The earth is struck by lightning thousands of time each minute, primarily around the equator. Subsequently, the earth carries an enormous negative charge. It's always electron-rich and can serve as a powerful and abundant supply of antioxidant free radical-busting electrons.

The human body appears to be finely tuned to "work" with the earth in the sense that there's a constant flow of energy between our bodies and the earth. When you put your feet on the ground, you absorb large amounts of negative electrons through the soles of your feet. In today's world, this is more important than ever, yet fewer people than ever actually connect with the earth in this way anymore. Free radical stress from exposure to mercury pollution, cigarettes, insecticides, pesticides, trans fats, and radiation, just to name a few, continually deplete your body of electrons.

"We now know that oxidative stress causes disease. It causes inflammation," Dr. Sinatra says. "[But] we have this Earth – Mother Earth, that's going to give us all these free electrons."

Recharge Your 'Batteries' with Grounding

Dr. Sinatra, like myself, is a proponent for CoQ10, as it is a major electron donor and helps turn over ATP, which is the energy generated within each of your body's cells. Amazingly, grounding can also enhance ATP, via another mechanism. How do dietary-derived, oral antioxidants compare to the electrons transferred from the earth through your skin? According to Dr. Sinatra:

"Whether you take antioxidants... or whether you get electron donors through the skin, what you're taking in -- into your skin, and taking in orally -- is going to be synergistic. It's going to help your body... What's a healthy lifestyle? It's eating healthy. It's avoiding sugars. It's avoiding trans fats. It's eating organic much of the time. It's avoiding pesticides, insecticides, and chemicals. It's drinking healthy water, breathing in healthy air, and getting healthy sunlight... In other words, taking in these natural energies is a healing energy. Grounding is another natural energy that everybody should do in their lives, because it just makes sense. It incorporates a healthier lifestyle."

Walking Barefoot Is a Valuable Aspect of a Healthy Lifestyle

Exercising barefoot outdoors is one of the most wonderful, inexpensive and powerful ways of incorporating Earthing into your daily life and will also help speed up tissue repair, as well as easing the muscle pain you sometimes get from strenuous exercise. A review of the available research, published January 2012 in the Journal of Environmental and Public Health, agrees with the concept of reaping health benefits when connecting to the Earth1. According to the authors:

"Mounting evidence suggests that the Earth's negative potential can create a stable internal bioelectrical environment for the normal functioning of all body systems. Moreover, oscillations of the intensity of the Earth's potential may be important for setting the biological clocks regulating diurnal body rhythms, such as cortisol secretion.

It is also well established that electrons from antioxidant molecules neutralize reactive oxygen species (ROS, or in popular terms, free radicals) involved in the body's immune and inflammatory responses. The National Library of Medicine's online resource PubMed lists 7021 studies and 522 review articles from a search of 'antioxidant + electron + free radical.' It is assumed that the influx of free electrons absorbed into the body through direct contact with the Earth likely neutralize ROS and thereby reduce acute and chronic inflammation. 

Throughout history, humans mostly walked barefoot or with footwear made of animal skins. They slept on the ground or on skins. Through direct contact or through perspiration-moistened animal skins used as footwear or sleeping mats, the ground's abundant free electrons were able to enter the body, which is electrically conductive. Through this mechanism, every part of the body could equilibrate with the electrical potential of the Earth, thereby stabilizing the electrical environment of all organs, tissues, and cells.

Modern lifestyle has increasingly separated humans from the primordial flow of Earth's electrons. For example, since the 1960s, we have increasingly worn insulating rubber or plastic soled shoes, instead of the traditional leather fashioned from hides. Rossi has lamented that the use of insulating materials in post-World War II shoes has separated us from the Earth's energy field. Obviously, we no longer sleep on the ground as we did in times past.

During recent decades, chronic illness, immune disorders, and inflammatory diseases have increased dramatically, and some researchers have cited environmental factors as the cause. However, the possibility of modern disconnection with the Earth's surface as a cause has not been considered. Much of the research reviewed in this paper points in that direction."

The Sunflower Experiment
Last year, Gary Schwartz, PhD, at the University of Arizona, performed an elegant experiment with sunflowers to demonstrate the powerful biological effects of grounding. As shown in the photos below, one set of sunflowers were connected to a grounded power outlet via a thin metal rod placed in the vase, connected to a wire.


The second set was connected to an outlet that was not grounded. All of the flowers were freshly picked, from the same area, at the same time, and the water came from the same source and had nothing added. The experiment was blind, so the experimenter was unaware of which outlet had been grounded.

Sunflower Experiment 01

Sunflower Experiment 01

Sunflower Experiment 01

Photos used with permission from Gary Schwartz.

As you can see, by the seventh day, one set is clearly wilting away, while the other still looks plump and fresh. As hypothesized, the set that kept their freshness were connected to the grounded outlet. Even more remarkable was the dramatic difference in overall survival -- the grounded flowers survived for another 10 days after the ungrounded set had shriveled up and died!

According to Clint Ober, this isn't so surprising since flowers growing in the ground receive a continuous supply of energy from the earth. The grounding rod used in this experiment effectively mimics this natural ground connection, allowing them to thrive longer, as if they'd never been plucked in the first place. So, can this concept translate into better health for you? There's compelling evidence it can, and does...

How Grounding Changes Your Blood
Grounding helps thin your blood by improving its zeta potential, which means it improves the energy between your red blood cells. Research has demonstrated it takes about 80 minutes for the free electrons from the earth to reach your blood stream and transform your blood.

Do you know what a high-sugar diet, smoking, radio frequencies and other toxic electromagnetic forces, emotional stress, anxiety, high cholesterol, and high uric acid levels do to your blood?

All of these make your blood hypercoagulable, meaning it makes it thick and slow-moving, which increases your risk of having a blood clot or stroke. Hypercoagulable blood is the essence of inflammation, because when your blood does not flow well, oxygen can't get to your tissues. In fact, grounding's effect on blood thinning is so profound if you are taking blood thinners you must work with your health care provider to lower your dose otherwise you may overdose on the medication.

Zeta potential is the electrical potential of solids and liquids, also referred to as electrokinetic potential. Your red blood cells repel each other and function at the speed of light, traveling through your body at an astounding 186,000 miles per second. Grounding actually increases zeta potential by an average of 280 percent. According to Dr. Sinatra:

"This is the most incredible discovery, because if you can increase the thinning of your blood naturally by grounding, you can fight off disease. Not only heart disease and stroke, but I'm thinking cancer, Alzheimer's, multiple sclerosis, or any illness that requires good oxygenation to the tissues."

Similarly, anything that lowers zeta potential of your blood will promote disease. For example, early (and some current) birth control pills were notorious for causing heart attacks in women. One of the mechanisms that causes this increased risk is that synthetic estrogens and progesterones increase blood viscosity, i.e., they decrease the zeta potential of your blood... There are currently studies being performed at the University of Arizona which will objectively document grounding effect on the zeta potential. They are anticipated to be completed this year.

Other Beneficial Changes Caused By Grounding
Animal experiments have also shown that ungrounded rats had higher blood sugar compared to their grounded counterparts, despite being fed identical diets. If disconnecting from the earth disrupts human sugar metabolism, we may have identified yet another contributing cause for the dramatic rise of diabetes in children.

"... I think the reason why we have a generation of diabetic kids is because we took away the ground, gave them a lot of sugar, and no exercise. That's the perfect storm," Dr. Sinatra says.

Experiments in Poland, the U.S. and Canada, using both animal and human models, show that grounding improves the human physiology. Other biochemical alterations caused by grounding include changes in:

•Phosphorus
•Calcium metabolism
•Fibroid metabolism
•White blood cells

Grounding also calms your sympathetic nervous system, which supports your heart rate variability. And, when you support heart rate variability, this promotes homeostatis, or balance, in your autonomic nervous system. In essence, anytime you improve heart rate variability, you're improving the entire organism -- in this case, your entire body and all its functions.

"In other words, we're there -- we're in a health mode, as opposed to disease mode. Grounding does that," Dr. Sinatra explains.

Contraindications and Other Warnings
While walking barefoot is clearly one of the most natural things you can possibly do to improve your health, there are still some contraindications and situations in which you may want to use caution.

"I don't like people to ground when they're taking Coumadin," Dr. Sinatra warns. "It's a relative contraindication because we have had people ground, taking Coumadin at the same time, and their blood became like water. It was like red wine and then it got really thin. That could be dangerous. If you have high blood pressure, [or]... if you had a stroke and you have thin blood, it's a disaster. We basically tell people that if you're on Coumadin, you must work with your doctor, because your doctor's going to have to reduce the Coumadin."

Depending on your health status and toxic load, your health may also get worse before it gets better when you start grounding on a regular basis. This is a classic detox reaction, which you may also experience with other detox methods.

"Some patients with polyneuropathy would get worsening of their limb pain on grounding, and some would get better. I want to make that clear that grounding is not a panacea," Dr. Sinatra says. "But what I've learned with grounding is that the sicker you are, the more you need to ground."

Sunday, August 27, 2017

Immune System of Human Body

The condition of the body is maintained at a constant level by modulating body temperature and blood pressure, to cope with changes in the environment inside and outside the body. This mechanism is called homeostasis. In homeostasis, the innate immune system plays an important role: it eliminates foreign substances (non-self) such as pathogens, viruses and cancer cells. However, it is known that immune function deteriorates with aging, and is impaired or stimulated by a poor lifestyle such as smoking, insufficient physical exertion or an unbalanced diet, and by adverse environmental changes and pollution. Deterioration of immune function causes or aggravates infection and malignant tumors, while excessive elevation of the immune system may cause things such as hay fever, atopic dermatitis or chronic inflammation. Studies in recent years have clarified that fiber and indigestive components in food are deeply involved in the maintenance of homeostasis and immune responsiveness.

バイオブランイメージ

BioBran is a functional food manufactured using a water-soluble rice bran dietary fiber component (hemicellulose B). Collaborative research with Prof. Mamdooh Ghoneum Ph.D. at the University of California, Los Angeles, USA (UCLA/Drew University of Medicine) on rice bran dietary fiber components has led to the discovery and establishment of processing and manufacturing methods of a food that optimally modulates the innate immune function of the body. It was subsequently demonstrated that BioBran has not only an immunostimulatory effect but also an immunomodulating effect. Extensive efforts to maximize its stability and taste have resulted in BioBran rice bran arabinoxylan. Currently, BioBran is widely used not only in Japan but also in more than 50 countries worldwide, and has an excellent reputation.
Patent No.5358219.

Daiwa Pharmaceutical Co., Ltd. has focused on a dietary fiber thought to have the potential to impact the immune response and developed a multifunctional food closely related to the Japanese foodstuff of ancient times, named BioBran (Rice Bran Arabinoxylan Compound).


Manufacturing Process




Characteristics

BioBran is a functional food produced by water-soluble dietary fiber (hemicellulose B) with an enzyme derived from shiitake mushrooms.

Suggested daily dose
1-3g/day

Property
Easy soluble in water and heat-stable

Mechanism of Action

Starch, dietary fiber, and BioBran are classified as polysaccharides. 
Starch is digested by saliva, pancreatic juice, and intestinal juice, and is absorbed in the small intestine as glucose. Dietary fiber is not digested, and is excreted unchanged. BioBran is known to be partly absorbed directly in the digestive tract, entering the blood stream.It activates the Natural Killer Cells, T cells, B cells, and macrophages, either directly in the blood, or indirectly via the Peyer's patch of the ileum, BioBran plays an important role in immunomodulation (immunostimulation, anti-inflammation, anti-allergy, antioxidation processes). Overall, it is considered to enhance the body's natural healing abilities, alleviate the adverse drug reactions of chemotherapeutic agents, and improve quality of life.







Usefulness as a functional food

1. Immunomodulatory action

(1) Immunostimulating action

▶Response of human NK cell activation to dose of BioBran
▶NK cell activation in cancer patients following BioBran intake
▶Stimulation of lymphocyte transformation
▶Promotion of differentiation of dendritic cells
▶Anticancer effect of BioBran

(2) Anti-inflammatory action

▶Influence on liver damage

2. Combination therapy with a chemotherapeutic agent

▶BioBran in combination with a chemotherapeutic agent

3. Improvement of quality of life

▶Effect of BioBran on survival and quality of life improvement in patients with progressive cancer

Safety

Single dose ~ LD50>36g/kg.
Repeated dose ~ NOAEL>200mg/kg/day.
Mutagenicity (Ames test) ~ Negative.

▶Response of human NK cell activation to dose of BioBran

Twenty-four healthy human volunteers were divided into three groups of 8, and assigned to ingest BioBran at 15mg/kg body weight (approximately equal to 1g), 30mg/kg body weight (approximately equal to 2g), and 45mg/kg body weight (approximately equal to 3g) every day for a period of two months to measure the effects on NK cell activity.

The activity in the 15mg/kg group was almost unchanged after 1 week but increased to twice the baseline activity after 1 month. The activity in the 30mg/kg group increased to about 3 times the baseline value after 1 week and then gradually increased to 5 times the baseline value by 2 months. The 45mg/kg group showed a pattern of increase similar to that in the 30mg/kg group, but the rate and degree of increase were greater than that of the 30mg/kg group. Following cessation of treatment, the NK cell activity levels gradually returned to baseline in each group.

Response of human NK cell activation to dose of BioBran

Response of human NK cell activation to dose of BioBran :

Ghoneum M.,“Enhancement of human natural killer cell activity by modified Arabinoxylan from rice bran (MGN-3)”, INT. J. IMMUNOTHERAPY XIV (2) 89-99 (1998)

▶NK cell activation in cancer patients following BioBran intake

NK cell activity was compared before and after 6 months of BioBran intake in 25 cancer patients with progressive disease, who received chemotherapy, surgery, and/or hormone therapy. Although a large difference in the baseline activity was observed between patients, all patients demonstrated an increase in NK cell activity after BioBran intake.

NK cell activation in cancer patients following BioBran intake

NK cell activation in cancer patients following BioBran intake :

Ghoneum M. and G. Namatalla, 87th Annual Meeting of the American Association for Cancer Research, 1996.

▶Stimulation of lymphocyte transformation

The proliferation of T-cell and B-cell lymphocytes was compared before and after BioBran intake. The proliferation of both T-cells and B-cells increased in the 3 patients following BioBran intake.

Stimulation of lymphocyte transformation

Stimulation of lymphocyte transformation:

Ghoneum M., 11th International AIDS Conference in Vancouver, 1996.

▶Promotion of differentiation of dendritic cells

Monocytes were isolated from the peripheral blood of healthy subjects and cultured in the presence of GM-CSF and IL-4 for 6 days, to prepare immature dendritic cells (iDC). On the 7th day, BioBran was added at various concentrations to the immature dendritic cells. The immature dendritic cells were incubated for 2 days and their maturation to dendritic cells was observed. The same operation was performed using two kinds of culture medium which have the effect of promoting the development of iDC to mature dendritic cells, designated mat DC1, and matDC2, respectively. In the immature dendritic cells (iDC), BioBran suppressed the expression of the monocyte marker CD14 and increased the expression of the dendritic cell marker CD83, both in a dose dependent manner. This result appears to show that BIoBran promotes the differentiation of dendritic cells.

Promotion of differentiation of dendritic cells

Promotion of differentiation of dendritic cells :

Cholujova D., et al, “BioBran-augmented maturation of human monocyte-derived dendritic cells”, NEOPLASMA, 56, 2, 2009.

▶Anticancer effect of BioBran

Female Swiss albino mice were inoculated with 2.5 x 106 Ehrlich ascites carcinoma (EAC) cells into the right femoral region, and the tumor size determined on consecutive days, starting on the 8th day after inoculation until the 35th day. The control group received phosphate buffered saline (PBS), and the BioBran group received 40 mg/kg body weight of BioBran intraperitoneally three times a week for a period of 3 weeks, starting on the 8th day after the inoculation of EAC. After treatment, the tumor size was determined. The results showed a significantly greater suppression of tumor growth in the BioBran group compared to the control (PBS) group, starting on the 14th day after inoculation of EAC. The photographs of tumor on the 35th day also showed a tumor regression in the BioBran group.

バイオブランのin vivoにおける抗腫瘍効果Anticancer effect of BioBran

バイオブランのin vivoにおける抗腫瘍効果
Anticancer effect of BioBran :

Ghoneum M., et al, “In vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice”, Nutrition and Cancer, 2008.

Influence on liver damage

Male Wistar rats (5 rats/group) were given intraperitoneal administration of 800 mg/kg D-galactosamine to induce liver disorder. Serum GOT and GPT were determined 24 hours after the administration of D-galactosamine, as induces of liver damage. One hour before administration of D-galactosamine, 20, 40, or 80 mg/kg of BioBran was administered intraperitoneally. The serum GOT and GPT in the control group without BioBran at 24 hours after the administration of D-galactosamine were 1410 IU/L and 445 IU/L, respectively. Compared to these values, serum GOT and GPT in the groups treated with BioBran were significantly lower at all doses.

Influence on liver damage

Influence on liver damage :

Sanada H. and Y. Egashira, 7th meeting of the Japanese Association for Dietary Fiber Research, Tokyo, 2002.


▶BioBran in combination with a chemotherapeutic agent

Human breast cancer cells (MCF-7) (1 x 104 cells) were seeded into the wells of a plate and incubated for 3 days in the presence of differing concentrations of BioBran, and the chemotherapeutic agent daunorubicin (DNR). Viable cells were counted by the MTT method, and the concentration of DNR which reduced the number of viable cancer cells by 50% (IC50) was determined. DNR inhibited the survival of MCF-7 cells in a concentration-dependent manner, with the IC50 being 1μM. When MCF-7 cells were cultured in the presence of BioBran and DNR, the IC50 of DNR for MCF-7 was reduced significantly (IC50: 0.2μM).

BioBran in combination with a chemotherapeutic agent

BioBran in combination with a chemotherapeutic agent :
Ghoneum M. and S. Gollapudi, “MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin”, Cancer Detection and Prevention, 2008.

▶Effect of BioBran on survival and quality of life improvement in patients with progressive cancer

Two hundred and five patients with malignant tumors who were receiving treatment with alternative therapy and chemotherapy with mild adverse drug reactions were allocated into two groups. One of the groups (the control group) received conventional alternative therapy and chemotherapy, and the other group (BioBran group) was given 1 g of BioBran three times a day after each meal for 18 months, in addition to receiving the same therapy as the control group. The correlation between natural killer (NK) cell activity determined during the observation period and survival rate was studied.
The patients’ quality of life was assessed on a scale of 0 to 4 with regard to “pain”, “fatigue”, and “nausea” and 0 to 3 with regard to “appetite” at the start of, and during, the observation period. Of the 205 patients participating in the study, 53 patients of the control group could not continue the conventional alternative therapy and dropped out, and therefore 152 patients (56 patients in the control group and 96 in the BioBran group) were included in the analysis. The survival rates at the end of the observation period in the control group and the BioBran group were 35.8% and 54.2%, respectively. This represents a 50% higher survival rate in the BioBran group compared to the control group. It was also shown that higher NK cell activity was associated with a higher survival rate (Table 1). It was confirmed that the patients’ quality of life after the study had improved compared to the quality of life at the start of the study in both the control group and BioBran group; a notable improvement in appetite was observed in the BioBran group (Table 2).

Effect of BioBran on survival and quality of life improvement in patients with progressive cancer

Effect of BioBran on survival and quality of life improvement in patients with progressive cancer :

Takahara K., et al, “The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer”, Clinical Pharmacology and Therapy, 2004

Tuesday, June 20, 2017

Chemical Elements In Human Body


Chemical elements listed by their presence in human body

The chemical elements of
the periodic chart sorted by:
Presence in human body (%)
Name of chemical element
Presence
- Name alphabetically65, in all liquids and tissues, bones, proteinsOxygenin all liquids and tissues, bones, proteins
- Atomic number18, everywhereCarboneverywhere
- Symbol10,
in all liquids and tissues, bones, proteins
Hydrogenin all liquids and tissues, bones, proteins
- Atomic Mass3,
in all liquids and tissues, proteins
Nitrogenin all liquids and tissues, proteins
- Electronegativity1,5,
lungs, kidney, liver, thyroid, brain, muscles, heart, bones
Calciumlungs, kidney, liver, thyroid, brain, muscles, heart, bones
- Density1,
urine, bones
Phosphorusurine, bones
- Melting point0,35
enzymes
Potassiumenzymes
- Boiling point0,25
proteins
Sulphurproteins
- Vanderwaals radius0,15
in all liquids and tissues (in terms of salt)
Sodiumin all liquids and tissues (in terms of salt)
- Year of discovery0,05
lungs, kidney, liver, thyroid, brain, muscles, heart
Magnesiumlungs, kidney, liver, thyroid, brain, muscles, heart
- Inventor surnametraces,
bones, teeth
Fluorinebones, teeth
- Elements in earthcrusttraces,
in body liquid
Chlorinein body liquid
- Elements in human bodytraces,
enzymes
Manganeseenzymes
- Covalenz radiustraces,
enzymes
Ironenzymes
- Ionization energytracesCobalt
For chemistry students and teachers: The tabular chart on the right is arranged by elements in human body.
The first chemical element with the highest percentage is Oxygen and the last one with the lowest percentage is Magnesium.
The unit for the elements in the human body is %.
Please note that the elements do not show their natural relation towards each other as in the Periodic system. There you can find the metals, semi-conductor(s), non-metal(s), inert noble gas(ses), Halogens, Lanthanoides, Actinoids (rare earth elements) and transition metals.
 
 
tracesCopper
tracesZinc
tracesSelenium
tracesMolybdenum
tracesIodine
minimum tracesLithium
minimum tracesAluminium
minimum tracesSilicon
minimum tracesVanadium
minimum tracesArsenic
minimum tracesBromine
minimum tracesStrontium
minimum tracesLead
Helium
Beryllium
Boron
Neon
Argon
Scandium
Titanium
Chromium
Nickel
Gallium
Germanium
Krypton
Rubidium
Yttrium
Zirconium
Nobelium
Technetium
Ruthenium
Rhodium
Palladium
Silver
Cadmium
Indium
Tin
Antimony
Tellurium
Xenon
Cesium
Barium
Lanthanum
Cerium
Praseodymium
Neodymium
Promethium
Samarium
Europium
Gadolinium
Terbium
Dysprosium
Holmium
Erbium
Thulium
Ytterbium
Lutetium
Hafnium
Tantalum
Tungsten
Rhenium
Osmium
Iridium
Platinum
Gold
Mercury
Thallium
Bismuth
Polonium
Astatine
Radon
Francium
Radium
Actinium
Thorium
Protactinium
Uranium
Neptunium
Plutonium
Americium
Curium
Berkelium
Californium
Einsteinium
Fermium
Mendelevium
Nobelium
Lawrencium
Rutherfordium
Dubnium
Seaborgium
Bohrium
Hassium
Meitnerium
Darmstadtium
Roentgenium
Ununbium
Ununtrium
Ununquadium
Ununpentium
Ununhexium
Ununseptium
Ununoctium




 

The chemical elements and water

The chemical elements of the periodic table and their interaction with water:
reaction mechanisms, environmental impact and health effects

Aluminium in water (AL + H2O) Argon in water (Ar + H2O)
Arsenic in water (As + H2O)
Boron in water (B + H2O)
Calcium in water (Ca + H2O)
Chromium in water (Cr + H2O)
Helium in water (He + H2O)
Iodine in water (I + H2O)
Iron in water (Fe + H2O)
Lead in water (Pb + H2O)
Lithium in water (Li + H2O)
Magnesium in water (Mg + H2O)
Nickel in water (Ni + H2O)
Nitrogen in water (N + H2O)
Oxygen in water (O2 + H2O)
Potassium in water (K + H2O)
Silicon in water (Si + H2O)
Silver in water (Ag + H2O)
Sodium in water (Na + H2O)
Strontium in water (Sr + H2O)
Tin in water (SN + H2O)
Titanium in water (Ti + H2O)
Zinc in water (Zn + H2O)

These pages should answer the following questions:

In what way and in what form do these elements react with water?

What is the solubility of these elements and what are the most important compounds?
Why are certain elements present in water?
What are the environmental effects of these chemical elements in water?
What are the health effects of specific elements and their compounds in water?
Which water purification technologies can be applied for removal of specific elements from water?
And additional information and literature sources.
Feeling knowledgeable on environmental topics? Try our environmental quiz!
 

Chemical elements listed by melting point


The elements of the periodic table sorted by melting point

click on any element's name for further chemical properties, environmental data or health effects.
This list contains the 118 elements of chemistry.
The chemical elements of
the periodic chart sorted by:
Melting-
point
Name chemical elementSymbolAtomic number
- Name alphabetically-272HeliumHe2
- Atomic number-259HydrogenH1
- Symbol-249NeonNe10
- Atomic Mass-220FluorineF9
- Electronegativity-218OxygenO8
- Density-210NitrogenN7
- Melting point-189ArgonAr18
- Boiling point-157KryptonKr36
- Vanderwaals radius-112XenonXe54
- Year of discovery-101ChlorineCl17
- Inventor surname-71RadonRn86
- Elements in earthcrust-39MercuryHg80
- Elements in human body-7BromineBr35
- Covalenz radius27FranciumFr87
- Ionization energy29CesiumCs55
For chemistry students and teachers: The tabular chart on the right is arranged by melting point.
The chemical element with the lowest melting point is Helium and the element with the highest melting point is Carbon.
The unity used for the melting point is Celsius (C). Click here: to convert Celsius to Fahrenheit or Kelvin.
Please note that the elements do not show their natural relation towards each other as in the Periodic system. There you can find the metals, semi-conductor(s), non-metal(s), inert noble gas(ses), Halogens, Lanthanoides, Actinoids (rare earth elements) and transition metals.
30GalliumGa31
39RubidiumRb37
44PhosphorusP15
64PotassiumK19
98SodiumNa11
113SulfurS16
114IodineI53
157IndiumIn49
180LithiumLi3
217SeleniumSe34
232TinSn50
254PoloniumPo84
271BismuthBi83
302AstatineAt85
303ThalliumTl81
321CadmiumCd48
327LeadPb82
420ZincZn30
449TelluriumTe52
630AntimonySb51
639MagnesiumMg12
640NeptuniumNp93
640PlutoniumPu94
660AluminumAl13
700RadiumRa88
725BariumBa56
769StrontiumSr38
795CeriumCe58
816.8ArsenicAs33
822EuropiumEu63
824YtterbiumYb70
827NobeliumNo102
839CalciumCa20
860EinsteiniumEs99
900CaliforniumCf98
920LanthanumLa57
935PraseodymiumPr59
937GermaniumGe32
962SilverAg47
986BerkeliumBk97
994AmericiumAm95
1010NeodymiumNd60
1050ActiniumAc89
1064GoldAu79
1072SamariumSm62
1083CopperCu29
1100PromethiumPm61
1132UraniumU92
1245ManganeseMn25
1278BerylliumBe4
1311GadoliniumGd64
1340CuriumCm96
1360TerbiumTb65
1410SiliconSi14
1412DysprosiumDy66
1453NickelNi28
1470HolmiumHo67
1495CobaltCo27
1522ErbiumEr68
1523YttriumY39
1527FermiumFm100
1535IronFe26
1539ScandiumSc21
1545ThuliumTm69
1552PalladiumPd46
1568ProtactiniumPa91
1627LawrenciumLr103
1656LutetiumLu71
1660TitaniumTi22
1750ThoriumTh90
1772PlatinumPt78
1852ZirconiumZr40
1857ChromiumCr24
1890VanadiumV23
1966RhodiumRh45
2150HafniumHf72
2200TechnetiumTc43
2250RutheniumRu44
2300BoronB5
2410IridiumIr77
2468NiobiumNb41
2617MolybdenumMo42
2996TantalumTa73
3045OsmiumOs76
3180RheniumRe75
3410TungstenW74
3500CarbonC6
MendeleviumMd101
RutherfordiumRf104
DubniumDb105
SeaborgiumSg106
BohriumBh107
HassiumHs108
MeitneriumMt109
DarmstadtiumDs110
RoentgeniumRg111
UnunbiumUub112
UnuntriumUut113
UnunquadiumUuq114
UnunpentiumUup115
UnunhexiumUuh116
UnunseptiumUus117






Chemical elements listed by boiling point


The elemenents of the periodic table sorted by boiling point


click on any element's name for further chemical properties, environmental data or health effects.
This list contains the 118 elements of chemistry.
The chemical elements of
the periodic chart sorted by:
Boiling-
point
Name chemical elementSymbolAtomic number
- Name alphabetically-269HeliumHe2
- Atomic number-253HydrogenH1
- Symbol-246NeonNe10
- Atomic Mass-196NitrogenN7
- Electronegativity-188FluorineF9
- Density-186ArgonAr18
- Melting point-183OxygenO8
- Boiling point-153KryptonKr36
- Vanderwaals radius-108XenonXe54
- Year of discovery-62RadonRn86
- Inventor surname-35ChlorineCl17
- Elements in earthcrust58.8 BromineBr35
- Elements in human body184IodineI53
- Covalenz radius280PhosphorusP15
- Ionization energy337AstatineAt85
 
For chemistry students and teachers: The tabular chart on the right is arranged by boiling point.
The chemical element with the lowest boiling point is Helium and the element with the highest boiling point is Tungsten.
The unity used for the melting point is Celsius (C). Click here: to convert Celsius to Fahrenheit or Kelvin.
Please note that the elements do not show their natural relation towards each other as in the Periodic system. There you can find the metals, semi-conductor(s), non-metal(s), inert noble gas(ses), Halogens, Lanthanoides, Actinoids (rare earth elements) and transition metals.
 
357MercuryHg80
445SulfurS16
613ArsenicAs33
677FranciumFr87
678CesiumCs55
685SeleniumSe34
688RubidiumRb37
760PotassiumK19
765CadmiumCd48
774PotassiumK19
883SodiumNa11
907ZincZn30
962PoloniumPo84
990TelluriumTe52
1090MagnesiumMg12
1140BariumBa56
1347 LithiumLi3
1384StrontiumSr38
1457ThalliumTl81
1466YtterbiumYb70
1484CalciumCa20
1560BismuthBi83
1597 EuropiumEu63
1727 ThuliumTm69
1737RadiumRa88
1740LeadPb82
1750AntimonySb51
1900SamariumSm62
1962ManganeseMn25
2000 IndiumIn49
2212 SilverAg47
2270 TinSn50
2355SiliconSi14
2403GalliumGa31
2467AluminumAl13
2510ErbiumEr68
2550BoronB5
2562DysprosiumDy66
2567CopperCu29
2607AmericiumAm95
2672ChromiumCr24
2720HolmiumHo67
2732NickelNi28
2750IronFe26
2807GoldAu79
2830GermaniumGe32
2832ScandiumSc21
2870CobaltCo27
2927PalladiumPd46
2970BerylliumBe4
3000PromethiumPm61
3041TerbiumTb65
3127PraseodymiumPr59
3127NeodymiumNd60
3200ActiniumAc89
3233GadoliniumGd64
3235PlutoniumPu94
3257CeriumCe58
3287TitaniumTi22
3315LutetiumLu71
3337YttriumY39
3380VanadiumV23
3469LanthanumLa57
3727RhodiumRh45
3818UraniumU92
3827PlatinumPt78
3900RutheniumRu44
3902NeptuniumNp93
4377ZirconiumZr40
4527IridiumIr77
4612MolybdenumMo42
4790ThoriumTh90
4827CarbonC6
4877TechnetiumTc43
4927NiobiumNb41
5027 OsmiumOs76
5400HafniumHf72
5425TantalumTa73
5627RheniumRe75
5660TungstenW74
ProtactiniumPa91
CuriumCm96
BerkeliumBk97
CaliforniumCf98
EinsteiniumEs99
FermiumFm100
MendeleviumMd101
NobeliumNo102
LawrenciumLr103
RutherfordiumRf104
DubniumDb105
SeaborgiumSg106
BohriumBh107
HassiumHs108
MeitneriumMt109
DarmstadtiumDs110
RoentgeniumRg111
UnunbiumUub112
UnuntriumUut113
UnunquadiumUuq114
UnunpentiumUup115
UnunhexiumUuh116
UnunseptiumUus117
UnunoctiumUuo118


 

UnunoctiumUuo
118