Neurotransmitter Histamine: An Alternative View Point
Abstract of Presentation at the 3rd Inter-Science World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators.
ABSTRACT FORM
Mail to
Scientific Secretariat
3rd Inter-Science World Conference on Inflammation
Instituto di Farmacologia
Via Roma, 55
56100 Pisa (Italy)
Dateline: JANUARY 30, 1989
(PUBLISHED; PAGE 37 OF THE ABSTRACT VOL.
3rd Inter-Science World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators.
Monte Carlo (Principality Of Monaco), March 15-18, 1989
In Win 89 )
Title: Neurotransmitter Histamine: An Alternative View Point
Authors: F. Batmanghelidj, M.D.
Institute: Foundation For The Simple In Medicine,
(Address): 2146, Kings Garden Way, Falls Church, VA. 22043, U.S.A.
ABSTRACT: Advances in histamine research show it to be a neurotransmitter, a neuromodulator and an osmoregulator of the body. While thirst sensation is a failing indicator of now recognized, age-dependent, state of possible cellular and chronic dehydration of the body, to the point that between the ages of twenty to seventy the ratio of the extracellular to the intracellular water content of the body has been shown to change from a figure of 0.8 to almost 1.1, histamine is demonstrating responsibility for the essential osmoregulatory and central dipsogenic functions in the body. Histamine is involved in the initiation of cellular cation exchange, that seems to be supplemental to the role of water in cellular metabolic mechanisms. Histamine is also a modulator of lymphocyte biology and function; through H1 or H2 activation of the different lymphocyte subpopulations that have nonrandom distribution of histamine receptors, their functions are integrated. Histaminergic drive for body water regulation and intake brings about the release of vasopressin which, in turn, by possible production of "shower head" cluster perforations of 2 Angstrom units, allowing the single file entry of one water molecule at a time through the membrane, promotes increased flow of water through the cell membrane. This function is particularly important for the maintenance of the low viscosity, microtubule directed, microstream flow of the axonal transport system. Vasopressin also acts as a modulating cortisone release factor when continuous and increased ACTH secretion can be implicated in the general inhibition of the immune system's functions; histamine may be involved in modulation of neuroendocrine systems, possibly when ACTH feedback mechanism is broken.Next to oxygen, water is the single most essential substance for the survival of the body, recognizing also that dry mouth is not the sole indicator of free water deficiency of the body, but a symptom producing excess histaminergic activity, including chronic pain production, and should also be judged to be an indicator of body water metabolism imbalance. The natural primary physiological drives of the histaminergenic. the serotonergic neurotransmission (another system involved in the body water regulation, as well as pain threshold alteration) and the angiotensin II for water intake of the body should be acknowledged and satisfied before and during evaluation of the clinical application of antihistamines in treatment procedures, particularly as increased water intake may be the only natural process for the regulation and inhibition of histamine's over-population and release. The prolonged use of antihistamines in gastroenterological, psychiatric - the seasonal allergic conditions - as analgesics or anti-inflammatory agents without very strict attention to the body water intake regulatory functions of histamine by making signals of dehydration, may eventually be the cause of cell membrane receptor down-regulation and disturb the integration and balance and, possibly, shift the immune system in an opposite dominant direction and, therefore, be responsible for the production of new and continuing change of physiological steady-state situations, incompatible with total and prolonged well-being of the patient.
Key-Words: Histamine, pain, inflammation, immunomodulation, thirst, water
========
[ Notes: Dipsogenic diabetes insipidus: a newly recognized syndrome caused by a selective defect in the osmoregulation of thirst.]
FORMAT FOR ABSTRACT
1. Your abstract should be informative, containing: (a) specific objectives; (b) methods; (c) summary of results; (d) conclusions.
2. Single space all typing. Capitalize all letters of the tile. The text should be a single paragraph, starting with a 3-space indentation. Leave no top or left margin within the area provided.
3. Abbreviations must be spelled out on first mention, followed by the abbreviation in parentheses.
4. Any special symbol that is not on your typewriter must be drawn in BLACK INK.
5. DO NOT ERASE. Remember that your abstract will appear in a special volume exactly as submitted.
6. Mail first class with 2 photo copies to address given above.
7. If more than one abstract submitted with the same author, indicate which abstract should have priority. Other abstracts will have a lower priority.
8. Please undeline speaker's name.
Abstract of Presentation at the 3rd Inter-Science World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators.
ABSTRACT FORM
Mail to
Scientific Secretariat
3rd Inter-Science World Conference on Inflammation
Instituto di Farmacologia
Via Roma, 55
56100 Pisa (Italy)
Dateline: JANUARY 30, 1989
(PUBLISHED; PAGE 37 OF THE ABSTRACT VOL.
3rd Inter-Science World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators.
Monte Carlo (Principality Of Monaco), March 15-18, 1989
In Win 89 )
Title: Neurotransmitter Histamine: An Alternative View Point
Authors: F. Batmanghelidj, M.D.
Institute: Foundation For The Simple In Medicine,
(Address): 2146, Kings Garden Way, Falls Church, VA. 22043, U.S.A.
ABSTRACT: Advances in histamine research show it to be a neurotransmitter, a neuromodulator and an osmoregulator of the body. While thirst sensation is a failing indicator of now recognized, age-dependent, state of possible cellular and chronic dehydration of the body, to the point that between the ages of twenty to seventy the ratio of the extracellular to the intracellular water content of the body has been shown to change from a figure of 0.8 to almost 1.1, histamine is demonstrating responsibility for the essential osmoregulatory and central dipsogenic functions in the body. Histamine is involved in the initiation of cellular cation exchange, that seems to be supplemental to the role of water in cellular metabolic mechanisms. Histamine is also a modulator of lymphocyte biology and function; through H1 or H2 activation of the different lymphocyte subpopulations that have nonrandom distribution of histamine receptors, their functions are integrated. Histaminergic drive for body water regulation and intake brings about the release of vasopressin which, in turn, by possible production of "shower head" cluster perforations of 2 Angstrom units, allowing the single file entry of one water molecule at a time through the membrane, promotes increased flow of water through the cell membrane. This function is particularly important for the maintenance of the low viscosity, microtubule directed, microstream flow of the axonal transport system. Vasopressin also acts as a modulating cortisone release factor when continuous and increased ACTH secretion can be implicated in the general inhibition of the immune system's functions; histamine may be involved in modulation of neuroendocrine systems, possibly when ACTH feedback mechanism is broken.Next to oxygen, water is the single most essential substance for the survival of the body, recognizing also that dry mouth is not the sole indicator of free water deficiency of the body, but a symptom producing excess histaminergic activity, including chronic pain production, and should also be judged to be an indicator of body water metabolism imbalance. The natural primary physiological drives of the histaminergenic. the serotonergic neurotransmission (another system involved in the body water regulation, as well as pain threshold alteration) and the angiotensin II for water intake of the body should be acknowledged and satisfied before and during evaluation of the clinical application of antihistamines in treatment procedures, particularly as increased water intake may be the only natural process for the regulation and inhibition of histamine's over-population and release. The prolonged use of antihistamines in gastroenterological, psychiatric - the seasonal allergic conditions - as analgesics or anti-inflammatory agents without very strict attention to the body water intake regulatory functions of histamine by making signals of dehydration, may eventually be the cause of cell membrane receptor down-regulation and disturb the integration and balance and, possibly, shift the immune system in an opposite dominant direction and, therefore, be responsible for the production of new and continuing change of physiological steady-state situations, incompatible with total and prolonged well-being of the patient.
Key-Words: Histamine, pain, inflammation, immunomodulation, thirst, water
========
[ Notes: Dipsogenic diabetes insipidus: a newly recognized syndrome caused by a selective defect in the osmoregulation of thirst.]
FORMAT FOR ABSTRACT
1. Your abstract should be informative, containing: (a) specific objectives; (b) methods; (c) summary of results; (d) conclusions.
2. Single space all typing. Capitalize all letters of the tile. The text should be a single paragraph, starting with a 3-space indentation. Leave no top or left margin within the area provided.
3. Abbreviations must be spelled out on first mention, followed by the abbreviation in parentheses.
4. Any special symbol that is not on your typewriter must be drawn in BLACK INK.
5. DO NOT ERASE. Remember that your abstract will appear in a special volume exactly as submitted.
6. Mail first class with 2 photo copies to address given above.
7. If more than one abstract submitted with the same author, indicate which abstract should have priority. Other abstracts will have a lower priority.
8. Please undeline speaker's name.
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