Depending on what area of the brain is more affected by dehydration. different subsets of labels have generated for the same basic problem.
Since you have been initiated into the field of psychiatry by the advertising programs of the drug industry, you likely want to know all about the relationship of water to serotonin and its re-uptake inhibitors, and so on, before you can begin to value water as an effective natural medication against depression.
There are 20 amino acids. from these, then body manufactures different proteins for construction of both body tissues and the active messenger agents that regulate the body's functions. The body has the ability to manufacture 10 of these amino acids, but the other 10 cannot be manufactured and must be imported. The 10 amino acids the body can make are alanine, glycine, proline, serine, cysteine, aspartic acid, glutamic acid, asparagines, glutamine, and tyrosine.
However, at least two of these amino acids -- cysteine and tyrosine -- are derivatives of other essential amino acids that the body cannot manufacture but must consume. Cysteine is manufactured from methionine, and tyrosine is manufactured from phenylalanine.
The human body can manufacture some histidine, but not enough of it during childhood and old age. For this reason, histidine should also be considered an essential amino acid.
The essential amino acids --- listed in the order of their importance for brai function --- are histidine, tryptophan, phenylalanine, methionine, lysine, threonine, valine, arginine, leucine, and isoleucine.
Histidine gets converted to the neurotransmitter histamine and is responsible for the water regulation and resource management of the body. It operates your thirst sensations and regulates the water rationing programs of the body. It is with us from minute one of life when the ovum is fertilized by the sperm, but has not yet divided into the two cells.
Histamine has to "wet-nurse" the ovum for it to be able to expand in volume and then divide, and divide, until the fetus-baby is born -- histamine is there all the time.
In childhood, when child body is growing, histamine acts as a strong growth factor, much like growth hormone. The difference is that histamine becomes more and more active as we grow older, while growth hormone activity diminished very rapidly from the third decade (30th-years)of life.
The tremendous need for the actions of histamine in childhood and old age makes its precursor amino acid, histidine, essential. many neurological disorders, such as multiple sclerosis (MS), seem to be produced because of histidine metabolism imbalance. many emotional problems are associated with excess activity of histamine during its water-regulation.
The more the human body becomes dehydrated (note: the body is already 2% dehydrated when you feel thirsty; so drink water prior to feeling thirsty to prevent dehydration kick-in; every 90 minute, drink at least 10% of your personal daily water quota; daily water quota is 31.42(ml) multiply with your present body weight digits (weight in kilogram); if your body weighs 65 kg, then 31.42 X 65 = 2042.3 ml is your daily personal water quota), the more histamine activity takes over the physiological functions that were the responsibility of water. If there is not enough water to energize the mineral pumps, or cation pumps, and regulate the balance between sodium (which has to stay outside the cells membranes) and potassium (which must be forced back in), histamine stimulates the release of energy to jump-start the protein pumps and bring about osmotic balance in the environment of the cells -- most vitally in the brain.
Histamine acts as a natural energy manager in the absence of water and shortage of hydroelectric energy. Warning: anti-histamine drugs in fact is fighting your body natural mechanism of surviving due to body dehydration; so the logical remedy is to drink water, not take in more anti-histamine pills.
Brain function is not efficient without histamine when the body is short of water. Nor is it efficient for long if it has to rely only on histamine as a substitute for the functions of water. In essence, this state of inefficient brain physiological, caused by the missing action of water, due to water deficit, is what we call depression.
Serotonin is the kingpin chemical, needed for many events that silently regulate the body physiology. This is why a shortage of the serotonin that should normally be available is one of the hallmarks of depression. It's is also why ( a trade secret, now, exposed !) the pharmaceutical industry has produced number of chemicals that slow down the rate of serotonin's destruction in the nerve terminals after it is secreted to perform one of its many functions:
1 of 11*Serotonin alters the threshold of pain sensation and produce analgesia.
2 of 11*Serotonin controls production and release of the growth hormone. Now you know why anti-histamine drug medications can have negative-side-effect upon normal growth in patients.
3 of 11*Serotonin controls the level of blood sugar.
4 of 11*Serotonin controls the blood pressure levels of the body - it has a tendency to lower blood pressure. If you drink enough water daily, your blood pressure level will be regulated within normal pressure.
5 of 11* Serotonin and tryptophan control appetite. You remember I talked about motilin, which is considered a kind of gut serotonin. It is the hormone that causes the satiety sensation.
You now understand the physiological upheaval that occurs as a result of tryptophan shortage in the brain tissue. After 20-plus years of research into relationship of water to pain regulation of the human body, I have reached a broad understanding of how to avoid serotonin depletion in the brain and prevent depression.