Wednesday, August 8, 2018

OSTEOPOROSIS ; Bones Dehydration


Osteoporosis is normally recognized in the sixth decade of life, although it often starts in the body fifteen to twenty years earlier. It occurs in both sexes and in all population groups. The total bone mass seems to decrease. It seems that the rate of bone resorption exceeds the rate of bone formation. Consequently, bone consistency and volume begin to decline. No one knows why osteoporosis occurs as we age. What I am about to discuss is my view. It is new and not necessarily subscribed to by others in the field of scientific research. 

By linking osteoporosis to chronic dehydration and a gradual rise in cholesterol levels of the body, I am sure I will incur the wrath of many of my colleagues who are looking at the condition through solutes-directed research. Be that as it may, the following is my scientific belief and worthy of being exposed. Should my views 
prevail, the solution to osteoporosis will become simple. It will be a matter of prevention, nine-tenths of any sensible cure. To expose the relationship between osteoporosis and dehydration, we need to understand how bone formation takes place in the human body. 

As an example, and depending on the availability of raw materials at a construction site, the use of concrete for the building of the skeleton of a building seems to be the most practical, long-lasting, and economical method. If sand, gravel, and cement are locally produced, water is the only other necessary element to mix these 
components and the interwoven steel rods, which act as internal trusses for the cement to hold on to, as well as providing the rigidity needed for any durable building construction. Exactly the same principle is employed in the manufacture of skeletal bones. 

The architecture of dense bones employs myriad interwoven collagen fibers. Single fibers are anchored together and woven into a three-ply band. The woven bands are laid side by side and anchored together. It seems these thicker rope like structures are now inter-woven in such a way that “hole zones” or gaps are created for the deposit of a number of different calcium and sodium crystals. While the elastic collagen fibers provide the inner scaffolding for the calcium, the calcium itself establishes the necessary rigidity for the bone to become weight-bearing. Also, much of the 24 percent deposit of sodium in the body—along with the other minerals, such as magnesium, that are not dissolved in extracellular fluid—is stored as crystals in the bone. Thus, bone formation depends on calcium, sodium, and, to a lesser degree, other mineral deposits. 

Now that we are discussing sodium, let us recognize an important fact. Sodium and its “attached” chloride or bicarbonate constitute 90 percent of all the solids dissolved in the fluid surrounding the cells of the body. Thus, sodium is the most important ingredient for the maintenance of extracellular fluid volume. Twenty-four percent of all the sodium in the body seems to be in a solid and crystalline form, mainly stored in the bones. The stored sodium in the bone must be assumed to compose the sodium reserves of the body, at the same time as it is employed for bone crystallization and rendering it hard. Thus, sodium in its own right serves an 
important function in the process of bone formation. Sodium shortage in the body, now that we understand its role in bone formation, may be a contributing factor in the establishment of osteoporosis. A sodium-free diet and the long-term use of diuretics may be a contributory factor in the establishment of osteoporosis. 

Collagen fibers are manufactured from amino acids that are connected in a linear fashion. The amino acid pool of the body seems to regulate the manufacture of these fibers. These fibrous strands are protected from being enzymatically broken if they are deeply embedded in the calcium deposits. As soon as the calcium is removed from around the fibers, their enzymatic breakdown and the reentry of their amino acid components into the amino acid pool becomes possible. This is how bone formation of the body has to do a balancing act between bone construction and bone breakdown. A tip of balance in the direction of one or the other state determines whether bone becomes thicker and more solid, or weak and lighter in construction. 

How does bone resorption takes place? How is it related to dehydration?

There are many different factors involved in bringing about bone resorption to the point of causing osteoporosis. I will not get involved in the variety of conditions that have bone resorption as their indirect consequence. I will concentrate on the possible direct relationship of dehydration to osteoporosis. Remember that there is normally a time gap between the expo-sure of a disease process and the initiating factors that began the process. In the case of the onset of chronic dehydration and its consequence of osteoporosis, my opinion is there may be a gap of one to three decades. 

It is my understanding that the very gradual loss of thirst sensation—the primary cause for the establishment of chronic dehydration—begins after the third decade of life, while the establishment of osteoporosis is mostly seen during the sixth decade of life. Thus, the tip of balance in favor of gradual and incipient bone 
resorption becomes established over the span of many years. Inactivity and disuse of the bone structure accentuate the rate of osteoporosis, while physical activity and the full use of the bones favor the laying down of calcium deposits and strengthening the frame of the bones. 

One of the main factors for the establishment of osteoporosis is the process of bone breakdown— osteolysis—that is brought about by prostaglandin E (PGE). As we know, PGE is a subordinate that routinely becomes active at the command of the neurotransmitter histamine. Bone marrow has an abundance of mast cells that  manufacture histamine. 

The consequence of the prolonged activation of PGE by histamine is tapping into the calcium reserves by means of the breakdown of bone (osteolysis) and the removal of calcium from the bone deposits. The removal of calcium exposes the collagen for ultimate breakdown. In this way, dehydration that commissions histamine into activity will produce the consequent osteoporosis in the bone structures of the body. Osteoporosis is the negative outcome between the rate of bone formation and osteolysis. The only way to decommission histamine and prevent the bone resorption that 
is associated with dehydration is to adequately increase daily water intake to no less than eight glasses of water, eight ounces each. You also need sufficient exercise to tip the balance in favor of bone formation. Exercise has many other beneficial effects, of course. Not only does it cause strengthening of the bone itself, as well as its joints and its muscle connections, but it also promotes better circulation—it opens and creates a more extensive capillary bed and builds a larger blood pool to draw on when the body is in need of more water and raw materials. This is why well-exercised people are able to endure hardship and stress with fewer detrimental effects. An adequate and balanced protein diet is also essential to 
maintain the amino acid pool that ultimately determines the rate of manufacture of different collagen fibers. 


In September 1987, I was asked to deliver the guest lecture at a select cancer conference and workshop, because I had introduced a new understanding to this major health problem of our society. I scientifically explained why chronic unintentional dehydration is, in my view, the primary cause of pain and disease in the human body, including cancer. I explained that dehydration produces a drastic system disturbance in the physiology of the body and causes four major disruptions that ultimately and collectively allow for cancer formation and the invasive growth of the new tissue. My lecture was published in the September-October 1987 issue 
of the Journal of Anticancer Research. You can retrieve this article from my Web site Further scientific information is available in my article “Neurotransmitter Histamine: An Alternative Viewpoint,” which was presented at The Third Interscience World Conference on Inflammation in 1989. In September 2002, I was invited for the second time to highlight my understanding of dehydration and cancer formation in the body at the Thirty-first Annual Cancer Control Society Conference in Los Angeles. 

The detailed explanations are too complicated for the scope of this book, but the highlights are as follows: 
Persistent dehydration causes a multi-system dysfunction in the entire physiology of the body, including: 

1. DNA damage in the cell nucleus 

2. Inefficiency and eventual loss of DNA repair system inside the cells 

3. Cell receptor abnormalities and loss of balancing processes of the hormonal control systems 

4. General immune system suppression, even at the level of the bone marrow, causing lack of ability to recognize abnormal cells, the inability to destroy them, and loss of the filter system for removal of abnormal and primitive genes from the time-refined and sophisticated gene pool in the body. 

In short, dehydration will gradually cause the body to lose its edge against the disruptive cascade of chemical combinations that constitute makeshift processes until the body gets back to its normal pattern of chemistry. You see, the body is a chemical refinery; it is the outcome of a most sophisticated pattern of chemical reactions that depend on the adequate presence of water and, naturally, other food-contained ingredients. If you shortchange it the water it needs to maintain efficiency and run the myriad chemical formulas every second of every minute of life, 
you cause the creation of new chemical pathways that produce pain, disease, and premature death. Cancer formation is the outcome of a series of such chemical formulas and pathways to early death. Four of these primary pathways have been ... (click here to continue reading)

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