Friday, August 3, 2018

DIABETES : Water Deficit in Brain

Chapter 7 Water for Healing, Water for health, Water for Life


Diabetes seems to be the end result of water deficiency in the brain, to the point that the brain's neurotransmitter systems, particularly the system that is regulated by the neurotransmitter serotonin, are affected. It is within the automatic design of the brain to peg up the glucose threshold so that it can maintain its own volume and energy requirements when there is a water shortage in the body. When there is a gradually establishing chronic dehydration in the body, the brain has to depend more on glucose as a source of energy. The brain needs more glucose for its energy value and its metabolic conversion to water. Under the urgent circumstances produced by stress, up to 85 percent of the supplemental energy requirement by the brain is provided by sugar alone. This is why stressed people resort to eating sweet food. While all the other cells need to be influenced by insulin to take up glucose through their cell walls, the brain does not depend on insulin to carry sugar across its cell membranes. 

It seems to be in the natural design of the brain to steer the physiological mechanisms in the direction of higher glucose level in the body when there is persistent dehydration that would damage the brain more than it could recover from. The brain resuscitates itself in the same way that a doctor resuscitates a patient— with intravenous fluid containing sugar and salt. The main problem stems from one very important factor— the salt metabolism (both sodium and potassium) of the body also becomes negatively affected when there is water deficiency in the body. This condition should be treated with an increase in water intake and diet manipulation to provide the necessary minerals and amino acid balance for tissue repair—including brain tissue requirements. 

It has been shown that the brain amino acid balance for tryptophan is affected in diabetic rats. There seems to be a much lower level of this amino acid in the brain when diabetes exists. Tryptophan in turn regulates the salt intake of the body. Salt is responsible for regulating water-volume content outside the cells of the body. 
When there is tryptophan deficiency in the body, there is also a total body-salt shortage. With lower salt retention as a result of tryptophan deficiency, the responsibility for holding water in the body and outside the cells falls onto the sugar content in the blood. To do its new job, and compensate for the lower salt, the sugar content rises. The way this happens is so simple it is almost unbelievable. 

One of histamine's deputies, which becomes increasingly active in water-distribution systems, is prostaglandin E. This chemical inhibits the insulin-making cells in the pancreas, preventing them from making and secreting insulin. When insulin is not adequately secreted, the main body cells do not receive sufficient sugar and some amino acids. Potassium stays outside the cells, and the water that accompanies potassium does not enter the cells, either. In this way, the cells of the body are forced to forgo their right to water and some amino acids, and they gradually become damaged. This is how diabetes becomes the cause of many associated disease conditions.

Diabetes is a good example of next-generation damage that is caused by dehydration. Whereas the onset of dehydration-induced diabetes is normally seen in the elderly and is often reversible, the more structurally serious and irreversible variety of the disease is seen in younger people. The juvenile variety of diabetes needs to be treated carefully before it becomes a totally irreversible type of diabetes and permanent structural damage takes place. Basically the cause is the same in children as in adults, except that in adults there is more “reserve in the system.” In children, the process of physical growth strains the system much more quickly. Children are constantly dehydrated, and their amino acid pool is in a state of constant fluctuation. 

At the moment, there seems to be total reliance on the belief that genetic dictation is what promotes the occurrence of diabetes, particularly in the young. One important fact to remember is that the DNA structure is held together by proteins that also obey the many dictates of water as their ultimate regulator. Water is the 
common factor for all protein functions in the body, including theDNA-manufacturing system. Accordingly, the associated genetic marker in diabetes may not be a dictating factor for disease production; rather, it may be the indicator of a deep-rooted, dehydration-caused damage that has also affected the DNA recording system—a passive outcome. 

Pancreas: The Failed Organ in Diabetes 

The pancreas, where insulin is made, is an organ that is directly involved in the regulation of the balance between the water compartments of the body. The water volume held inside each cell is regulated and held by the amount of potassium that is forced into the cell. Insulin is a very effective agent for forcing potassium (and amino acids) inside the cells. If potassium stays outside the cells and in circulation, at a certain threshold it can produce irregular heartbeats and, often, a sudden heart seizure and stopping of the heart's rhythmic contractions. In effect, therefore, insulin regulates water volume inside the cell. It manages this responsibility by pushing potassium and sugar into the cell that has insulin-sensitive gates of entry on its outer membrane. 

The pancreas has another equally important responsibility. It has to collect water from some of its cells, mix it with manufactured bicarbonate and pancreatic enzymes, and secrete the mixture into the intestine to neutralize the acid that is poured into the intestine from the stomach and begin the next phase of digestion of food. The mixture is known as watery bicarbonate solution

The Role of the Pancreas in Water Rationing 

If water is in short supply, the watery bicarbonate solution that is secreted into the intestine cells may not be enough to neutralize all the acid that enters the intestine to begin the cycle of food digestion. Consequently, one or the other process has to be halted. Either the acid has to stop coming into the intestine, or water has to be delivered to the pancreas in a sufficient amount for the pancreas to perform at least one of its functions. A commensurate reduction of insulin secretion stops the entry of water and nutrients into the peripheral cells in the rest of the body that depend on the presence of insulin for their feeding process. By this process, more water will be available in the circulating blood to be delivered to the pancreas to make its watery bicarbonate solution. When the insulin-stimulated gates are not efficient in delivering water and raw materials into the cells, they begin to wither and die. This is the mechanism behind the degenerative process associated with diabetes. 

In dyspeptic cases, acid will continue to build up in the stomach. The ring muscle between the stomach and the intestine will close the gap, and nothing will enter the intestine. The more the stomach contracts to push its load into the intestine, the tighter the ring will contract. Only a fraction of the load is let out. Over time, 
ulcerations in the ring area are produced. In this situation, the full acid load does not enter into the intestine, and less demand is placed on the pancreas for secretion of its watery bicarbonate solution. 

In diabetes, the action of insulin in pushing water into the cells is stopped. This is done simply by a two-step process: The first step, a reversible one, is to prevent insulin secretion from the cells that manufacture it. This type of diabetes is called insulin-independent diabetes. The pancreas has the ability to secrete insulin. A second, and much more drastic, ruthless, and irreversible way, is to destroy the insulin-making cells. The process involves the destruction of their nuclei. Enough of their DNA/RNA system is dismembered to make them ineffective as insulin producers. This kind of diabetes is known as insulin-dependent or type I diabetes. 

Insulin-Independent Diabetes (Type-2)

This form of diabetes is often reversible. When the insulin-secreting cells are temporarily inhibited by prostaglandin E, certain outside agents can override this and get insulin released. The knowledge of this process of insulin release has been used in devising a simpler treatment procedure than insulin injections. The agents that release insulin are given in tablet form, usually one tablet once a day. 

These tablets are normally given to elderly diabetics and not to young ones.  There are side effects to these tablets, including abnormalities in blood cell countand blood cell composition, jaundice, gastro-intestinal symptoms, liver-function 
problems, and skin rashes. Hypo-glycemic coma is also a complication of overdose of these tablets, often the result of forgetful repeat of medication. The use of these drugs is dangerous in liver disease and kidney-function irregularities or deficiency. 

In insulin-independent diabetes, a regular daily adjustment of water intake to no less than two quarts, and some increased salt intake, is the best treatment. In this form of diabetes, when the body makes some insulin but does not release it because of the effect of prostaglandin E, water intake and adjustment of diet and minerals often will reverse the situation, and the need for higher blood sugar will subside. 

Insulin-Dependent Diabetes (Type-1)

Diabetes can become permanently established when there is DNA/RNA damage. In this type of diabetes, the ability to manufacture insulin is lost. If prostaglandin E remains in general circulation long enough, it activates the hormone interleukin-6. 
This chemical works its way into the nucleus of insulin-producing cells and gradually dismembers the DNA/RNA scaffolding of the nucleus, decreasing its size and reducing its ability to function. Thus water deficiency, if uncorrected for a long time, can in many people cause damage—sometimes permanent—to their insulin- 
producing cells. 

Subsequently, even more damage to the diabetic body can occur. Some organs begin to suffer and become useless. A leg can shrink and become gangrenous, if not amputated; cysts can form in the brain; eyes can become blind. 

Diabetes in Children 

In children, the process is the same, except it begins at a much earlier age until it becomes an “autoimmune” disease. That is to say, the insulin-producing cells are destroyed to avoid the need for constant control of their activity (see figure 7.4). The body of a child has much less water reserve than that of a grown person. It seems logical to assume that the gap between the inhibition of insulin release and the threshold of insulin cell destruction must also be less wide. Adding to this problem is the fact that a growing body is always dehydrated. Every cell in the soft tissues needs about 75 percent of its volume to be water to function within the norms of the human body. 

When the body is growing under the influence of growth hormone, as well as other hormones, and the effect of histamine with its food-and water-supply regulation, a form of stress is constantly experienced. This stimulates the thirst sensation, and the body will demand water. Plain water should be given, although some 
parents force their own habits of drinking sodas, tea, or juices on their children. 

Nothing—but nothing—can substitute for water to satisfy the water needs of the body. It is true that other drinks contain some water, but they do not affect the body in the same way as water itself. The vitamins contained in fresh fruit juices are essential for the body. Still, too much of any juice—particularly orange and grapefruit juice—can be harmful. Juices can increase the acidity of the intestine and then the body. Their high potassium content can drastically increase the activation and presence of histamine. This will signal undue stress to the body, and a crisis water-rationing state will develop. 

The physical growth of the body of a child is an adaptive response to the stresses and demands placed on it. It grows as a result of this stress, and histamine's activities are an essential part of the process.


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